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10.1016/bs.mie.2017.01.007 http://scihub22266oqcxt.onion/10.1016/bs.mie.2017.01.007 C5642287!5642287!28411646     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28411646&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Methods+Enzymol 2017 ; 590 (ä): 381-411 Nephropedia Template TP {{tp|p=28411646|t=2017. Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes |pdf=|usr=}}{{28411646}} gab.com Text Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes JO: Methods Enzymol http://www.kidney.de/pget.php?&tw=1&pmid=28411646 #FOAvip Proteins have the potential to replace synthetic small molecule drugs due to their specificity and selectivity in their activity. However, if administered in their native form, they can aggregate leading to immunogenicity or get cleared by renal and reticuloendothelial system which ultimately hampers their efficacy as therapeutic agents. Thus, the formulation in which proteins are administered plays a key role in retaining their biological activity and lowering immunogenicity while minimizing the dosage requirements. Enzyme-wrapping, using synthetic polymers, is a strategy employed to provide enzymes with lower immunogenicity, longer circulation times and better targeting capabilities. Protein-polymer complexation methods, involving covalent, non-covalent and electrostatic interactions, that can provide means to develop formulations for retaining enzyme stability are discussed in this chapter. Twit Text FOAVip Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes ????Methods Enzymol http://www.kidney.de/pget.php?&tw=1&pmid=28411646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28411646 #FOAvip English Wikipedia <ref>{{Cite pmid|28411646}}</ref> Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes #MMPMID28411646 Raghupathi K; Thayumanavan S Methods Enzymol 2017[]; 590 (ä): 381-411 PMID28411646show ga Proteins have the potential to replace synthetic small molecule drugs due to their specificity and selectivity in their activity. However, if administered in their native form, they can aggregate leading to immunogenicity or get cleared by renal and reticuloendothelial system which ultimately hampers their efficacy as therapeutic agents. Thus, the formulation in which proteins are administered plays a key role in retaining their biological activity and lowering immunogenicity while minimizing the dosage requirements. Enzyme-wrapping, using synthetic polymers, is a strategy employed to provide enzymes with lower immunogenicity, longer circulation times and better targeting capabilities. Protein-polymer complexation methods, involving covalent, non-covalent and electrostatic interactions, that can provide means to develop formulations for retaining enzyme stability are discussed in this chapter. äNano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes (epmc).pdf DeepDyve Pubget Overpricing