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10.1016/j.immuni.2017.04.009

http://scihub22266oqcxt.onion/10.1016/j.immuni.2017.04.009
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C5640164!5640164!28514675
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suck abstract from ncbi

pmid28514675      Immunity 2017 ; 46 (5): 743-55
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  • Metabolic regulation of the immune humoral response #MMPMID28514675
  • Boothby M; Rickert RC
  • Immunity 2017[May]; 46 (5): 743-55 PMID28514675show ga
  • Productive humoral responses require that naïve B cells and their differentiated progeny move among distinct micro-environments. In this review, we discuss how studies are beginning to address the nature of these niches as well as the interplay between cellular signaling, metabolic programming, and adaptation to the locale. Recent work adds evidence to the expectation that B cells at distinct stages of development or functional subsets are influenced by the altered profiles of nutrients and metabolic by-products that distinguish these sites. Moreover, emerging findings reveal a cross-talk among the external milieu, signal transduction pathways, and transcription factors that direct B cell fate in the periphery.
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