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10.1038/mi.2017.32 http://scihub22266oqcxt.onion/10.1038/mi.2017.32 C5638662!5638662!28401938     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2018 ; 11 (1): 199-208 Nephropedia Template TP {{tp|p=28401938|t=2018. Novel Protective Mechanism for Interleukin-33 at the Mucosal Barrier during Influenza-associated Bacterial Super-infection |pdf=|usr=}}{{28401938}} gab.com Text Novel Protective Mechanism for Interleukin-33 at the Mucosal Barrier during Influenza-associated Bacterial Super-infection JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28401938 #FOAvip Influenza A is a highly contagious respiratory virus that causes seasonal epidemics and occasional worldwide pandemics. The primary cause of influenza-related mortality is bacterial super-infection. There are numerous mechanisms by which preceding influenza infection attenuates host defense, allowing for increased susceptibility to bacterial pneumonia. Herein, we demonstrate that influenza inhibits Staphylococcus aureus-induced production of IL-33. Restoration of IL-33 during influenza A and MRSA super-infection enhanced bacterial clearance and improved mortality. ILC2s and alternatively activated macrophages are not required for IL-33 mediated protection during super-infection. We show that IL-33 treatment resulted in neutrophil recruitment to the lung, associated with improved bacterial clearance. These findings identify a novel role for IL-33 in anti-bacterial host defense at the mucosal barrier. Twit Text FOAVip Novel Protective Mechanism for Interleukin-33 at the Mucosal Barrier during Influenza-associated Bacterial Super-infection ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28401938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28401938 #FOAvip English Wikipedia <ref>{{Cite pmid|28401938}}</ref> Novel Protective Mechanism for Interleukin-33 at the Mucosal Barrier during Influenza-associated Bacterial Super-infection #MMPMID28401938 Robinson KM; Ramanan K; Clay ME; McHugh KJ; Rich HE; Alcorn JF Mucosal Immunol 2018[Jan]; 11 (1): 199-208 PMID28401938show ga Influenza A is a highly contagious respiratory virus that causes seasonal epidemics and occasional worldwide pandemics. The primary cause of influenza-related mortality is bacterial super-infection. There are numerous mechanisms by which preceding influenza infection attenuates host defense, allowing for increased susceptibility to bacterial pneumonia. Herein, we demonstrate that influenza inhibits Staphylococcus aureus-induced production of IL-33. Restoration of IL-33 during influenza A and MRSA super-infection enhanced bacterial clearance and improved mortality. ILC2s and alternatively activated macrophages are not required for IL-33 mediated protection during super-infection. We show that IL-33 treatment resulted in neutrophil recruitment to the lung, associated with improved bacterial clearance. These findings identify a novel role for IL-33 in anti-bacterial host defense at the mucosal barrier. äNovel Protective Mechanism for Interleukin-33 at the Mucosal Barrier d(epmc).pdf DeepDyve Pubget Overpricing