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2017 ; 124
(5
): 697-700
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Re-evaluating the Incidence of Idiopathic Intracranial Hypertension in an Era of
Increasing Obesity
#MMPMID28187976
Kilgore KP
; Lee MS
; Leavitt JA
; Mokri B
; Hodge DO
; Frank RD
; Chen JJ
Ophthalmology
2017[May]; 124
(5
): 697-700
PMID28187976
show ga
PURPOSE: To re-evaluate the population-based incidence of idiopathic intracranial
hypertension (IIH) and to determine if it mirrors the rise in obesity. DESIGN:
Retrospective, population-based cohort. PARTICIPANTS: All residents of Olmsted
County, Minnesota, diagnosed with IIH between January 1, 1990, and December
31, 2014. METHODS: All cases of IIH were identified using the Rochester
Epidemiology Project, which is a record-linkage system of medical records for all
patient-physician encounters among Olmsted County, Minnesota, residents. All
medical records were reviewed to confirm a diagnosis of IIH. The incidence rates
of IIH were compared against the incidence of obesity in Minnesota over the same
period. MAIN OUTCOME MEASURES: Incidence of IIH, lumbar puncture opening
pressures, and body mass index. RESULTS: There were 63 new cases of IIH, yielding
an overall age- and gender-adjusted annual incidence of 1.8 per 100?000 (95%
confidence interval, 1.3-2.2) between 1990 and 2014. It increased from 1.0 per
100?000 (1990-2001) to 2.4 per 100?000 (2002-2014; P = 0.007). The incidence of
IIH was 3.3 per 100?000 in women and 0.3 per 100?000 in men (P ? 0.001). In obese
women 15 to 44 years of age, the incidence was 22.0 per 100?000 compared with 6.8
per 100?000 among all women in the same age group. A strong correlation was
observed between IIH incidence rates and obesity rates in Minnesota (R(2) = 0.70,
P = 0.008). CONCLUSIONS: The incidence of IIH has increased since 1990, which is
highly correlated with the rise in obesity during the same period.