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10.1073/pnas.1704962114 http://scihub22266oqcxt.onion/10.1073/pnas.1704962114 C5635877!5635877!28923960     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (40): E8411-20 Nephropedia Template TP {{tp|p=28923960|t=2017. IgH isotype-specific B cell receptor expression influences B cell fate |pdf=|usr=}}{{28923960}} gab.com Text IgH isotype-specific B cell receptor expression influences B cell fate JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28923960 #FOAvip B cells produce antibodies in the context of immunoglobulin heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE). Each of these is generated either as secreted proteins or as membrane-bound B cell antigen receptors (BCRs). While much is known about how IgH isotype dictates effector function of soluble antibodies, the role of antibody isotype in the context of BCRs is not well defined. Here we demonstrate that the membrane-bound versions (mIg) of IgM, IgG1, and IgE are produced from their natural genomic loci in a hierarchal fashion, where mRNA transcripts for mIgM are always more dominant than mIgG1, which are always more dominant than mIgE, regardless of cell stage. These isotype-specific expression differences contribute to B cell regulation. Twit Text FOAVip IgH isotype-specific B cell receptor expression influences B cell fate ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28923960 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28923960 #FOAvip English Wikipedia <ref>{{Cite pmid|28923960}}</ref> IgH isotype-specific B cell receptor expression influences B cell fate #MMPMID28923960 Tong P; Granato A; Zuo T; Chaudhary N; Zuiani A; Han SS; Donthula R; Shrestha A; Sen D; Magee JM; Gallagher MP; van der Poel CE; Carroll MC; Wesemann DR Proc Natl Acad Sci U S A 2017[Oct]; 114 (40): E8411-20 PMID28923960show ga B cells produce antibodies in the context of immunoglobulin heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE). Each of these is generated either as secreted proteins or as membrane-bound B cell antigen receptors (BCRs). While much is known about how IgH isotype dictates effector function of soluble antibodies, the role of antibody isotype in the context of BCRs is not well defined. Here we demonstrate that the membrane-bound versions (mIg) of IgM, IgG1, and IgE are produced from their natural genomic loci in a hierarchal fashion, where mRNA transcripts for mIgM are always more dominant than mIgG1, which are always more dominant than mIgE, regardless of cell stage. These isotype-specific expression differences contribute to B cell regulation. äIgH isotype-specific B cell receptor expression influences B cell fate(epmc).pdf DeepDyve Pubget Overpricing