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10.1038/s41467-017-00928-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-00928-3 C5635038!5635038 !29018261     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29018261 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 846 Nephropedia Template TP {{tp|p=29018261 |t=2017. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice |pdf=|usr=}}{{29018261 }} gab.com Text Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29018261 #FOAvip The aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc-Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection. Twit Text FOAVip Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29018261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29018261 #FOAvip English Wikipedia <ref>{{Cite pmid|29018261 }}</ref> Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice #MMPMID29018261 He W ; Chen CJ ; Mullarkey CE ; Hamilton JR ; Wong CK ; Leon PE ; Uccellini MB ; Chromikova V ; Henry C ; Hoffman KW ; Lim JK ; Wilson PC ; Miller MS ; Krammer F ; Palese P ; Tan GS Nat Commun 2017[Oct]; 8 (1 ): 846 PMID29018261 show ga The aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc-Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection. |*Macrophage Activation [MESH] |A549 Cells [MESH] |Animals [MESH] |Antibodies, Neutralizing/*physiology [MESH] |Dogs [MESH] |Female [MESH] |HEK293 Cells [MESH] |Hemagglutinins/immunology [MESH] |Humans [MESH] |Influenza A virus/*immunology [MESH] |Influenza, Human/*immunology [MESH] |Killer Cells, Natural/physiology [MESH] |Macrophages, Alveolar/*physiology [MESH] |Madin Darby Canine Kidney Cells [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neutrophils/physiology [MESH] |Orthomyxoviridae Infections/immunology [MESH] |Phagocytosis [MESH]Alveolar macrophages are critical for broadly-reactive antibody-mediat(epmc).pdf DeepDyve Pubget Overpricing