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10.1080/19490976.2017.1310357 http://scihub22266oqcxt.onion/10.1080/19490976.2017.1310357 C5628655!5628655!28384049     free     free     free       Gut+Microbes 2017 ; 8 (5): 486-92 Nephropedia Template TP {{tp|p=28384049|t=2017. Intestinal IgA as a modulator of the gut microbiota |pdf=|usr=}}{{28384049}} gab.com Text Intestinal IgA as a modulator of the gut microbiota JO: Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=28384049 #FOAvip Accumulating evidence suggests that dysbiosis plays a role in the pathogenesis of intestinal diseases including inflammatory bowel disease (IBD) as well as extra-intestinal disorders. As a modulator of the intestinal microbiota, we isolated a mouse monoclonal IgA antibody (clone W27) with high affinities for multiple commensal bacteria, but not for beneficial bacteria such as Lactobacillus casei (L. casei). Via specific recognition of an epitope in serine hydroxymethyltransferase (SHMT), a bacterial metabolic enzyme, W27 IgA selectively inhibited the in vitro growth of bound bacteria, including Escherichia coli (E. coli), while having no effect on unbound beneficial bacteria such as L. casei. By modulating the gut microbiota in vivo, oral administration of W27 IgA effectively prevented development of colitis in several mouse models. Here we discuss how intestinal IgA modulates the gut microbiota through recognition of SHMT. Twit Text FOAVip Intestinal IgA as a modulator of the gut microbiota ????Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=28384049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28384049 #FOAvip English Wikipedia <ref>{{Cite pmid|28384049}}</ref> Intestinal IgA as a modulator of the gut microbiota #MMPMID28384049 Okai S; Usui F; Ohta M; Mori H; Kurokawa K; Matsumoto S; Kato T; Miyauchi E; Ohno H; Shinkura R Gut Microbes 2017[]; 8 (5): 486-92 PMID28384049show ga Accumulating evidence suggests that dysbiosis plays a role in the pathogenesis of intestinal diseases including inflammatory bowel disease (IBD) as well as extra-intestinal disorders. As a modulator of the intestinal microbiota, we isolated a mouse monoclonal IgA antibody (clone W27) with high affinities for multiple commensal bacteria, but not for beneficial bacteria such as Lactobacillus casei (L. casei). Via specific recognition of an epitope in serine hydroxymethyltransferase (SHMT), a bacterial metabolic enzyme, W27 IgA selectively inhibited the in vitro growth of bound bacteria, including Escherichia coli (E. coli), while having no effect on unbound beneficial bacteria such as L. casei. By modulating the gut microbiota in vivo, oral administration of W27 IgA effectively prevented development of colitis in several mouse models. Here we discuss how intestinal IgA modulates the gut microbiota through recognition of SHMT. äIntestinal IgA as a modulator of the gut microbiota (epmc).pdf DeepDyve Pubget Overpricing