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10.1083/jcb.201612125

http://scihub22266oqcxt.onion/10.1083/jcb.201612125
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C5626537!5626537!28877994
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suck abstract from ncbi


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pmid28877994      J+Cell+Biol 2017 ; 216 (10): 3073-85
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  • Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling #MMPMID28877994
  • Kourtidis A; Necela B; Lin WH; Lu R; Feathers RW; Asmann YW; Thompson EA; Anastasiadis PZ
  • J Cell Biol 2017[Oct]; 216 (10): 3073-85 PMID28877994show ga
  • Kourtidis et al. demonstrate that cadherin complexes at the zonula adherens recruit a diverse set of mRNAs to a junction-associated RISC, via PLEKHA7. In this way, PLEKHA7 regulates expression of critical regulators of epithelial homeostasis, such as JUN, MYC, and SOX2, through Ago2 and miRNA-mediated silencing.
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