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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Cell+Biol 2017 ; 216 (10): 3073-85 Nephropedia Template TP
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Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling #MMPMID28877994
Kourtidis A; Necela B; Lin WH; Lu R; Feathers RW; Asmann YW; Thompson EA; Anastasiadis PZ
J Cell Biol 2017[Oct]; 216 (10): 3073-85 PMID28877994show ga
Kourtidis et al. demonstrate that cadherin complexes at the zonula adherens recruit a diverse set of mRNAs to a junction-associated RISC, via PLEKHA7. In this way, PLEKHA7 regulates expression of critical regulators of epithelial homeostasis, such as JUN, MYC, and SOX2, through Ago2 and miRNA-mediated silencing.