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10.7554/eLife.29738 http://scihub22266oqcxt.onion/10.7554/eLife.29738 C5626482!5626482 !28971799     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28971799 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI |pdf=|usr=}}{{28971799 }} gab.com Text Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28971799 #FOAvip Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases. Twit Text FOAVip Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28971799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28971799 #FOAvip English Wikipedia <ref>{{Cite pmid|28971799 }}</ref> Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI #MMPMID28971799 Absinta M ; Ha SK ; Nair G ; Sati P ; Luciano NJ ; Palisoc M ; Louveau A ; Zaghloul KA ; Pittaluga S ; Kipnis J ; Reich DS Elife 2017[Oct]; 6 (ä): ä PMID28971799 show ga Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases. |Animals [MESH] |Callithrix [MESH] |Humans [MESH] |Lymphatic Vessels/*anatomy & histology/*diagnostic imaging [MESH] |Magnetic Resonance Imaging/*methods [MESH]Human and nonhuman primate meninges harbor lymphatic vessels that can (epmc).pdf DeepDyve Pubget Overpricing