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10.1073/pnas.1710799114

http://scihub22266oqcxt.onion/10.1073/pnas.1710799114
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C5625929!5625929!28874566
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suck abstract from ncbi


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pmid28874566      Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (39): E8244-53
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  • Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype #MMPMID28874566
  • Oberstein A; Shenk T
  • Proc Natl Acad Sci U S A 2017[Sep]; 114 (39): E8244-53 PMID28874566show ga
  • Human cytomegalovirus (HCMV) causes birth defects and serious disease in immunocompromised patients. We do not fully understand the cellular processes that HCMV manipulates during infection. A holistic understanding of the cellular response to HCMV will help clarify mechanisms that underlie its replication and spread. This work uses systems virology to globally map the host response to HCMV infection. Our method identifies unappreciated pathways modulated by HCMV, including mesenchymal-to-epithelial transition (MET), an important developmental pathway involved in epithelial tissue formation, wound healing, and cancer metastasis. Our findings demonstrate that HCMV induces MET and raise the possibility that the transition influences not only viral pathogenesis but also the behavior of normal and diseased cells within an infected human host.
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