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10.1073/pnas.1705599114 http://scihub22266oqcxt.onion/10.1073/pnas.1705599114 C5625908!5625908!28894001     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (39): 10443-8 Nephropedia Template TP {{tp|p=28894001|t=2017. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development |pdf=|usr=}}{{28894001}} gab.com Text Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28894001 #FOAvip Past and current treatments for type 1 diabetes (T1D) have all suffered from adverse effects due to severe immune suppression or a lack of efficacy. A better understanding of the mechanisms and limitations of these therapies may help to maximize patient responses to treatment or elicit new ideas for a cure. Here, we discover a role for intestinal type 1 regulatory T (Tr1) cells in preventing autoimmune diabetes and provide mechanistic insight to explain the better efficacy of combination therapy in disease treatment. Our results also highlight the influence of dysbiotic gut microbiota on promotion of intestinal Tr1 cells and suggest that strategies targeting mucosal tissue to induce Tr1 in vivo might be used as a therapeutic approach for T1D. Twit Text FOAVip Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28894001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28894001 #FOAvip English Wikipedia <ref>{{Cite pmid|28894001}}</ref> Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development #MMPMID28894001 Yu H; Gagliani N; Ishigame H; Huber S; Zhu S; Esplugues E; Herold KC; Wen L; Flavell RA Proc Natl Acad Sci U S A 2017[Sep]; 114 (39): 10443-8 PMID28894001show ga Past and current treatments for type 1 diabetes (T1D) have all suffered from adverse effects due to severe immune suppression or a lack of efficacy. A better understanding of the mechanisms and limitations of these therapies may help to maximize patient responses to treatment or elicit new ideas for a cure. Here, we discover a role for intestinal type 1 regulatory T (Tr1) cells in preventing autoimmune diabetes and provide mechanistic insight to explain the better efficacy of combination therapy in disease treatment. Our results also highlight the influence of dysbiotic gut microbiota on promotion of intestinal Tr1 cells and suggest that strategies targeting mucosal tissue to induce Tr1 in vivo might be used as a therapeutic approach for T1D. äIntestinal type 1 regulatory T cells migrate to periphery to suppress (epmc).pdf DeepDyve Pubget Overpricing