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10.1073/pnas.1701428114 http://scihub22266oqcxt.onion/10.1073/pnas.1701428114 C5625893!5625893!28893990     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (39): 10449-54 Nephropedia Template TP {{tp|p=28893990|t=2017. CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation |pdf=|usr=}}{{28893990}} gab.com Text CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28893990 #FOAvip Invariant natural killer T (iNKT) cells recognize lipid antigens in the context of CD1d and have potent effects on immunity. Control of iNKT cells is critical to prevent inflammation, but the mechanisms that maintain homeostasis of iNKT cells in peripheral tissues are incompletely understood. Here we demonstrate that hepatocytes promote the apoptosis of local, liver-resident iNKT cells in a manner dependent on CD1d. In the absence of hepatocyte CD1d or microsomal triglyceride transfer protein, a protein responsible for lipid transfer onto CD1d, hepatic iNKT cell numbers are increased, which is associated with susceptibility to iNKT cell-dependent hepatitis. This work thus reveals a pathway of peripheral induction of immune tolerance, which limits susceptibility to iNKT cell-dependent inflammation in the liver. Twit Text FOAVip CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28893990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28893990 #FOAvip English Wikipedia <ref>{{Cite pmid|28893990}}</ref> CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation #MMPMID28893990 Zeissig S; Peuker K; Iyer S; Gensollen T; Dougan SK; Olszak T; Kaser A; Blumberg RS Proc Natl Acad Sci U S A 2017[Sep]; 114 (39): 10449-54 PMID28893990show ga Invariant natural killer T (iNKT) cells recognize lipid antigens in the context of CD1d and have potent effects on immunity. Control of iNKT cells is critical to prevent inflammation, but the mechanisms that maintain homeostasis of iNKT cells in peripheral tissues are incompletely understood. Here we demonstrate that hepatocytes promote the apoptosis of local, liver-resident iNKT cells in a manner dependent on CD1d. In the absence of hepatocyte CD1d or microsomal triglyceride transfer protein, a protein responsible for lipid transfer onto CD1d, hepatic iNKT cell numbers are increased, which is associated with susceptibility to iNKT cell-dependent hepatitis. This work thus reveals a pathway of peripheral induction of immune tolerance, which limits susceptibility to iNKT cell-dependent inflammation in the liver. äCD1d-Restricted pathways in hepatocytes control local natural killer T(epmc).pdf DeepDyve Pubget Overpricing