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10.1038/nature24023 http://scihub22266oqcxt.onion/10.1038/nature24023 C5624508!5624508!28959974     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 549 (7673): 548-52 Nephropedia Template TP {{tp|p=28959974|t=2017. Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN |pdf=|usr=}}{{28959974}} gab.com Text Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28959974 #FOAvip Classical non-homologous end joining 1 (cNHEJ) and homologous recombination 2 (HR) compete for the repair of double stranded breaks of DNA during the cell cycle. HR is inhibited in G1 phase of the cell cycle, but both pathways are active in S and G2 phases. Why cNHEJ does not always outcompete HR in S and G2 phases has been unclear. Here we show that CYREN is a cell cycle specific inhibitor of cNHEJ. CYREN suppression allows cNHEJ at telomeres and intrachromosomal breaks during S and G2 phases, while cells lacking CYREN accumulate chromosomal aberrations upon damage induction, specifically outside G1 phase. CYREN acts by binding to the Ku70/80 heterodimer and preferentially inhibits cNHEJ at breaks with overhangs by protecting them. We therefore propose that CYREN is a direct cell cycle inhibitor of cNHEJ, thereby promoting error free repair by HR in cell cycle phases where sister chromatids are present. Twit Text FOAVip Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28959974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28959974 #FOAvip English Wikipedia <ref>{{Cite pmid|28959974}}</ref> Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN #MMPMID28959974 Arnoult N; Correia A; Ma J; Merlo A; Garcia-Gomez S; Maric M; Tognetti M; Benner CW; Boulton SJ; Saghatelian A; Karlseder J Nature 2017[Sep]; 549 (7673): 548-52 PMID28959974show ga Classical non-homologous end joining 1 (cNHEJ) and homologous recombination 2 (HR) compete for the repair of double stranded breaks of DNA during the cell cycle. HR is inhibited in G1 phase of the cell cycle, but both pathways are active in S and G2 phases. Why cNHEJ does not always outcompete HR in S and G2 phases has been unclear. Here we show that CYREN is a cell cycle specific inhibitor of cNHEJ. CYREN suppression allows cNHEJ at telomeres and intrachromosomal breaks during S and G2 phases, while cells lacking CYREN accumulate chromosomal aberrations upon damage induction, specifically outside G1 phase. CYREN acts by binding to the Ku70/80 heterodimer and preferentially inhibits cNHEJ at breaks with overhangs by protecting them. We therefore propose that CYREN is a direct cell cycle inhibitor of cNHEJ, thereby promoting error free repair by HR in cell cycle phases where sister chromatids are present. äRegulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor (epmc).pdf DeepDyve Pubget Overpricing