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10.1155/2017/9524594 http://scihub22266oqcxt.onion/10.1155/2017/9524594 C5623776!5623776 !29097850     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29097850 &cmd=llinks): Failed to open stream: HTTP request failed! 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Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder |pdf=|usr=}}{{29097850 }} gab.com Text Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29097850 #FOAvip Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular matrix degradation related to an imbalance between elastolytic enzymes released from inflammatory and resident cells and their naturally occurring inhibitors. However, the cause of this imbalance is still an object of investigation. In order to shed light on the role of fibroblasts in MDE, we used fibroblast cultures from MDE and control subjects to evaluate matrix metalloproteinases (MMPs) and their major inhibitor TIMP-1, which in combination with neutrophil or macrophage proteases released in inflamed areas may influence the elastolytic burden. We demonstrate that fibroblasts derived from MDE produce in vitro low levels of TIMP-1, the major inhibitor of MMPs. Elevated levels of MMP-2, MMP-14, and TIMP-2 capable to activate in a cooperative manner pro-MMP-2 are present in MDE tissue samples. Additionally, significant reaction for MMP-1 is present in the same MDE areas. These data all together suggest that ECM changes in MDE are due to cooperation of different cell populations (i.e., inflammatory cells and fibroblasts). Twit Text FOAVip Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=29097850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29097850 #FOAvip English Wikipedia <ref>{{Cite pmid|29097850 }}</ref> Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory Cells to the Elastolytic Disorder #MMPMID29097850 De Cunto G ; Lamberti A ; de Santi MM ; Miracco C ; Fimiani M ; Lungarella G ; Cavarra E Mediators Inflamm 2017[]; 2017 (ä): 9524594 PMID29097850 show ga Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular matrix degradation related to an imbalance between elastolytic enzymes released from inflammatory and resident cells and their naturally occurring inhibitors. However, the cause of this imbalance is still an object of investigation. In order to shed light on the role of fibroblasts in MDE, we used fibroblast cultures from MDE and control subjects to evaluate matrix metalloproteinases (MMPs) and their major inhibitor TIMP-1, which in combination with neutrophil or macrophage proteases released in inflamed areas may influence the elastolytic burden. We demonstrate that fibroblasts derived from MDE produce in vitro low levels of TIMP-1, the major inhibitor of MMPs. Elevated levels of MMP-2, MMP-14, and TIMP-2 capable to activate in a cooperative manner pro-MMP-2 are present in MDE tissue samples. Additionally, significant reaction for MMP-1 is present in the same MDE areas. These data all together suggest that ECM changes in MDE are due to cooperation of different cell populations (i.e., inflammatory cells and fibroblasts). |Cells, Cultured [MESH] |Female [MESH] |Fibroblasts/immunology/*metabolism [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinases/metabolism [MESH] |Microscopy [MESH] |Middle Aged [MESH] |Skin Diseases/immunology/*metabolism [MESH] |Skin/immunology/metabolism/pathology [MESH] |Tissue Inhibitor of Metalloproteinase-1/metabolism [MESH]Middermal Elastolysis: Dermal Fibroblasts Cooperate with Inflammatory (epmc).pdf DeepDyve Pubget Overpricing