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10.1016/j.bbcan.2017.03.001 http://scihub22266oqcxt.onion/10.1016/j.bbcan.2017.03.001 C5623098!5623098!28274726     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2017 ; 1867 (2): 109-26 Nephropedia Template TP {{tp|p=28274726|t=2017. A population genetics perspective on the determinants of intra-tumor heterogeneity |pdf=|usr=}}{{28274726}} gab.com Text A population genetics perspective on the determinants of intra-tumor heterogeneity JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=28274726 #FOAvip Cancer results from the acquisition of somatic alterations in a microevolutionary process that typically occurs over many years, much of which is occult. Understanding the evolutionary dynamics that are operative at different stages of progression in individual tumors might inform the earlier detection, diagnosis, and treatment of cancer. Although these processes cannot be directly observed, the resultant spatiotemporal patterns of genetic variation amongst tumor cells encode their evolutionary histories. Such intra-tumor heterogeneity is pervasive not only at the genomic level, but also at the transcriptomic, phenotypic, and cellular levels. Given the implications for precision medicine, the accurate quantification of heterogeneity within and between tumors has become a major focus of current research. In this review, we provide a population genetics perspective on the determinants of intra-tumor heterogeneity and approaches to quantify genetic diversity. We summarize evidence for different modes of evolution based on recent cancer genome sequencing studies and discuss emerging evolutionary strategies to therapeutically exploit tumor heterogeneity. Twit Text FOAVip A population genetics perspective on the determinants of intra-tumor heterogeneity ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=28274726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28274726 #FOAvip English Wikipedia <ref>{{Cite pmid|28274726}}</ref> A population genetics perspective on the determinants of intra-tumor heterogeneity #MMPMID28274726 Hu Z; Sun R; Curtis C Biochim Biophys Acta 2017[Apr]; 1867 (2): 109-26 PMID28274726show ga Cancer results from the acquisition of somatic alterations in a microevolutionary process that typically occurs over many years, much of which is occult. Understanding the evolutionary dynamics that are operative at different stages of progression in individual tumors might inform the earlier detection, diagnosis, and treatment of cancer. Although these processes cannot be directly observed, the resultant spatiotemporal patterns of genetic variation amongst tumor cells encode their evolutionary histories. Such intra-tumor heterogeneity is pervasive not only at the genomic level, but also at the transcriptomic, phenotypic, and cellular levels. Given the implications for precision medicine, the accurate quantification of heterogeneity within and between tumors has become a major focus of current research. In this review, we provide a population genetics perspective on the determinants of intra-tumor heterogeneity and approaches to quantify genetic diversity. We summarize evidence for different modes of evolution based on recent cancer genome sequencing studies and discuss emerging evolutionary strategies to therapeutically exploit tumor heterogeneity. äA population genetics perspective on the determinants of intra-tumor h(epmc).pdf DeepDyve Pubget Overpricing