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10.1016/j.brainresbull.2016.12.003 http://scihub22266oqcxt.onion/10.1016/j.brainresbull.2016.12.003 C5623095!5623095!27993598     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Res+Bull 2017 ; 133 (ä): 60-70 Nephropedia Template TP {{tp|p=27993598|t=2017. Role of Neurotoxicants and Traumatic Brain Injury in ?-Synuclein Protein Misfolding and Aggregation |pdf=|usr=}}{{27993598}} gab.com Text Role of Neurotoxicants and Traumatic Brain Injury in -Synuclein Protein Misfolding and Aggregation JO: Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=27993598 #FOAvip Protein misfolding and aggregation are key pathological features of many neurodegenerative diseases including Parkinson?s disease (PD) and other forms of human Parkinsonism. PD is a complex and multifaceted disorder whose etiology is not fully understood. However, several lines of evidence support the multiple hit hypothesis that genetic vulnerability and environmental toxicants converge to trigger PD pathology. Alpha-synuclein (?-Syn) aggregation in the brain is an important pathophysiological characteristic of synucleinopathies including PD. Epidemiological and experimental studies have shown that metals and pesticides play a crucial role in ?-Syn aggregation leading to the onset of various neurodegenerative diseases including PD. In this review, we will emphasize key findings of several epidemiological as well as experimental studies of metal- and pesticide-induced ?-Syn aggregation and neurodegeneration. We will also discuss other factors such as traumatic brain injury and oxidative insult in the context of ?-Syn-related neurodegenerative processes. Twit Text FOAVip Role of Neurotoxicants and Traumatic Brain Injury in -Synuclein Protein Misfolding and Aggregation ????Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=27993598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27993598 #FOAvip English Wikipedia <ref>{{Cite pmid|27993598}}</ref> Role of Neurotoxicants and Traumatic Brain Injury in ?-Synuclein Protein Misfolding and Aggregation #MMPMID27993598 Rokad D; Ghaisas S; Harischandra DS; Jin H; Anantharam V; Kanthasamy A; Kanthasamy AG Brain Res Bull 2017[Jul]; 133 (ä): 60-70 PMID27993598show ga Protein misfolding and aggregation are key pathological features of many neurodegenerative diseases including Parkinson?s disease (PD) and other forms of human Parkinsonism. PD is a complex and multifaceted disorder whose etiology is not fully understood. However, several lines of evidence support the multiple hit hypothesis that genetic vulnerability and environmental toxicants converge to trigger PD pathology. Alpha-synuclein (?-Syn) aggregation in the brain is an important pathophysiological characteristic of synucleinopathies including PD. Epidemiological and experimental studies have shown that metals and pesticides play a crucial role in ?-Syn aggregation leading to the onset of various neurodegenerative diseases including PD. In this review, we will emphasize key findings of several epidemiological as well as experimental studies of metal- and pesticide-induced ?-Syn aggregation and neurodegeneration. We will also discuss other factors such as traumatic brain injury and oxidative insult in the context of ?-Syn-related neurodegenerative processes. äRole of Neurotoxicants and Traumatic Brain Injury in ?-Synuclein Prote(epmc).pdf DeepDyve Pubget Overpricing