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10.1021/bi300846p

http://scihub22266oqcxt.onion/10.1021/bi300846p
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C5621923!5621923!22954137
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suck abstract from ncbi


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pmid22954137      Biochemistry 2012 ; 51 (38): 7433-43
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  • Measurement and Modeling of Signaling at the Single-Cell Level #MMPMID22954137
  • Kolitz SE; Lauffenburger DA
  • Biochemistry 2012[Sep]; 51 (38): 7433-43 PMID22954137show ga
  • It has long been recognized that a deeper understanding of cell function, with respect to execution of phenotypic behaviors and their regulation by the extracellular environment, is likely to be offered by analyzing the underlying molecular processes for individual cells selected from across a population, rather than averages of many cells comprising that population. In recent years experimental and computational methods for undertaking these analyses have advanced rapidly. In this review article we provide a perspective on both measurement and modeling facets of biochemistry at a single-cell level. Our central focus is on receptor-mediated signaling networks that regulate cell phenotypic functions.
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