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2017 ; 67
(5
): 430-435
Nephropedia Template TP
gab.com Text
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English Wikipedia
Sequelae of Occult Aggression Disqualifying Young, Socially Housed, Female New
Zealand White Rabbits (Oryctolagus cuniculus) from Participation in Dermal
Toxicology Studies
#MMPMID28935005
Comp Med
2017[Oct]; 67
(5
): 430-435
PMID28935005
show ga
International animal welfare organizations and federal, regional, and
institutional oversight bodies encourage social housing of gregarious species,
such as New Zealand white rabbits (Oryctolagus cuniculus), to promote animal
wellbeing in research, teaching, testing and farming settings. At our
institution, 2 groups of female New Zealand white rabbits (approximate age, 11
wk; mean weight, 2.35 kg), compatibly paired at the vendor for 5 wk, were paired
in caging or group-housed in a floor pen. The rabbits appeared compatible,
demonstrating primarily affiliative behaviors throughout 6 wk of daily
observations. However, occult aggression that occurred between daily observations
or nocturnally resulted in skin wounding. The skin injuries, first identified
during prestudy clipping of fur from the back of each rabbit 6 wk after arrival,
disqualified every animal from participation in skin toxicology and muscle
implantation studies. Success meeting scientific research requirements while
promoting animal welfare and health when socially housing New Zealand white
rabbits requires examining the behavioral repertoire of their wild counterparts,
European rabbits. Factors including age, sex, and housing density influence
territoriality, dominance hierarchy, social ranking, and natural, agonistic,
injurious, behavioral tendencies. IACUC and other relevant oversight bodies,
researchers, and animal care staff should consider this case study and the
species-specific natural history of New Zealand white rabbits when assessing the
harm and benefit of social housing in regard to research utility and animal
welfare.