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10.1016/j.bone.2017.03.047 http://scihub22266oqcxt.onion/10.1016/j.bone.2017.03.047 C5621379!5621379!28347910     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bone 2017 ; 100 (ä): 100-9 Nephropedia Template TP {{tp|p=28347910|t=2017. Acute lung injury complicating acute kidney injury: A model of endogenous ?Klotho deficiency and distant organ dysfunction |pdf=|usr=}}{{28347910}} gab.com Text Acute lung injury complicating acute kidney injury: A model of endogenous Klotho deficiency and distant organ dysfunction JO: Bone http://www.kidney.de/pget.php?&tw=1&pmid=28347910 #FOAvip The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic alpha-Klotho (?Klotho) protein was discovered when its genetic disruption led to premature multi-organ degeneration and early death. The extracellular domain of ?Klotho is cleaved by secretases and released into circulation as endocrine soluble ?Klotho protein, exerting wide-ranging cytoprotective effects including anti-oxidation on distant organs including the lung, which exhibits high sensitivity to circulating ?Klotho insufficiency. Because circulating ?Klotho is derived mainly from the kidney, acute kidney injury (AKI) leads to systemic ?Klotho deficiency that in turn increases the risks of pulmonary complications, i.e., edema and inflammation, culminating in the acute respiratory distress syndrome. Exogenous ?Klotho increases endogenous anti-oxidative capacity partly via activation of the Nrf2 pathway to protect lungs against injury caused by direct hyperoxia exposure or AKI. This article reviews the current knowledge of ?Klotho antioxidation in the lung in the setting of AKI as a model of circulating ?Klotho deficiency, an under-recognized condition that weakens innate cytoprotective defenses and contributes to the dysfunction in distant organs. Twit Text FOAVip Acute lung injury complicating acute kidney injury: A model of endogenous Klotho deficiency and distant organ dysfunction ????Bone http://www.kidney.de/pget.php?&tw=1&pmid=28347910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28347910 #FOAvip English Wikipedia <ref>{{Cite pmid|28347910}}</ref> Acute lung injury complicating acute kidney injury: A model of endogenous ?Klotho deficiency and distant organ dysfunction #MMPMID28347910 Hsia CC; Ravikumar P; Ye J Bone 2017[Jul]; 100 (ä): 100-9 PMID28347910show ga The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic alpha-Klotho (?Klotho) protein was discovered when its genetic disruption led to premature multi-organ degeneration and early death. The extracellular domain of ?Klotho is cleaved by secretases and released into circulation as endocrine soluble ?Klotho protein, exerting wide-ranging cytoprotective effects including anti-oxidation on distant organs including the lung, which exhibits high sensitivity to circulating ?Klotho insufficiency. Because circulating ?Klotho is derived mainly from the kidney, acute kidney injury (AKI) leads to systemic ?Klotho deficiency that in turn increases the risks of pulmonary complications, i.e., edema and inflammation, culminating in the acute respiratory distress syndrome. Exogenous ?Klotho increases endogenous anti-oxidative capacity partly via activation of the Nrf2 pathway to protect lungs against injury caused by direct hyperoxia exposure or AKI. This article reviews the current knowledge of ?Klotho antioxidation in the lung in the setting of AKI as a model of circulating ?Klotho deficiency, an under-recognized condition that weakens innate cytoprotective defenses and contributes to the dysfunction in distant organs. äAcute lung injury complicating acute kidney injury: A model of endogen(epmc).pdf DeepDyve Pubget Overpricing