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10.1080/19466315.2016.1174147

http://scihub22266oqcxt.onion/10.1080/19466315.2016.1174147
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suck abstract from ncbi


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pmid28966721      Stat+Biopharm+Res 2017 ; 9 (1): 25-34
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  • Single-Arm Phase II Survival Trial Design Under the Proportional Hazards Model #MMPMID28966721
  • Wu J
  • Stat Biopharm Res 2017[]; 9 (1): 25-34 PMID28966721show ga
  • For designing single-arm phase II trials with time-to-event endpoints, a sample size formula is derived for the modified one-sample log-rank test under the proportional hazards model. The derived formula enables new methods for designing trials that allow a flexible choice of the underlying survival distribution. Simulation results showed that the proposed formula provides an accurate estimation of sample size. The sample size calculation has been implemented in an R function for the purpose of trial design.
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