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2017 ; 2017
(ä): 7304121
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Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising
Future or Blind Alley?
#MMPMID29098010
Horák J
; Nalos L
; Martínková V
; Bene? J
; ?tengl M
; Mat?jovi? M
Stem Cells Int
2017[]; 2017
(ä): 7304121
PMID29098010
show ga
Sepsis, newly defined as a life-threatening organ dysfunction caused by a
dysregulated host response to infection, is the most common cause of death in
ICUs and one of the principal causes of death worldwide. Although substantial
progress has been made in the understanding of fundamental mechanisms of sepsis,
translation of these advances into clinically effective therapies has been
disappointing. Given the extreme complexity of sepsis pathogenesis, the paradigm
"one disease, one drug" is obviously flawed and combinations of multiple targets
that involve early immunomodulation and cellular protection are needed. In this
context, the immune-reprogramming properties of cell-based therapy using
mesenchymal stem cells (MSC) represent an emerging therapeutic strategy in sepsis
and associated organ dysfunction. This article provides an update of the current
knowledge regarding MSC in preclinical models of sepsis and sepsis-induced acute
kidney injury. Recommendations for further translational research in this field
are discussed.