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10.1016/j.celrep.2017.08.090 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.08.090 C5618720!5618720!28930689     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 20 (12): 2966-79 Nephropedia Template TP {{tp|p=28930689|t=2017. Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program |pdf=|usr=}}{{28930689}} gab.com Text Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28930689 #FOAvip Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies including leukemia. GATA-2-regulated enhancers regulate Gata2 expression in hematopoietic stem/progenitor cells and control hematopoiesis. The +9.5 kb enhancer activates transcription in endothelium and hematopoietic stem cells (HSCs), and its deletion abrogates HSC generation. The ?77 kb enhancer activates transcription in myeloid progenitors, and its deletion impairs differentiation. Since +9.5?/? embryos are HSC-deficient, it was unclear whether the +9.5 functions in progenitors or if GATA-2 expression in progenitors solely requires ?77. We further dissected the mechanisms using ?77;+9.5 compound heterozygous (CH) mice. The embryonic lethal CH mutation depleted megakaryocyte-erythrocyte progenitors (MEPs). While the +9.5 suffices for HSC generation, the ?77 and +9.5 must reside on one allele to induce MEPs. The ?77 generated Burst Forming Unit-Erythroid through induction of GATA-1 and other GATA-2 targets. The enhancer circuits controlled signaling pathways that orchestrate a GATA factor-dependent blood development program. Twit Text FOAVip Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28930689 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28930689 #FOAvip English Wikipedia <ref>{{Cite pmid|28930689}}</ref> Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program #MMPMID28930689 Mehta C; Johnson KD; Gao X; Ong IM; Katsumura KR; McIver SC; Ranheim EA; Bresnick EH Cell Rep 2017[Sep]; 20 (12): 2966-79 PMID28930689show ga Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies including leukemia. GATA-2-regulated enhancers regulate Gata2 expression in hematopoietic stem/progenitor cells and control hematopoiesis. The +9.5 kb enhancer activates transcription in endothelium and hematopoietic stem cells (HSCs), and its deletion abrogates HSC generation. The ?77 kb enhancer activates transcription in myeloid progenitors, and its deletion impairs differentiation. Since +9.5?/? embryos are HSC-deficient, it was unclear whether the +9.5 functions in progenitors or if GATA-2 expression in progenitors solely requires ?77. We further dissected the mechanisms using ?77;+9.5 compound heterozygous (CH) mice. The embryonic lethal CH mutation depleted megakaryocyte-erythrocyte progenitors (MEPs). While the +9.5 suffices for HSC generation, the ?77 and +9.5 must reside on one allele to induce MEPs. The ?77 generated Burst Forming Unit-Erythroid through induction of GATA-1 and other GATA-2 targets. The enhancer circuits controlled signaling pathways that orchestrate a GATA factor-dependent blood development program. äIntegrating Enhancer Mechanisms to Establish a Hierarchical Blood Deve(epmc).pdf DeepDyve Pubget Overpricing