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10.3390/ijms18091999 http://scihub22266oqcxt.onion/10.3390/ijms18091999 C5618648!5618648 !28926977     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28926977 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma |pdf=|usr=}}{{28926977 }} gab.com Text Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28926977 #FOAvip Immunomodulatory drugs (IMiDs) are profoundly active compounds in the treatment of patients with multiple myeloma (MM). However, despite the fact that treatment with IMiDs has dramatically improved survival for patients with MM, the majority of MM patients develop IMiDs resistance over time. We have found that expression of functional cereblon is required for IMiDs' action. In addition, it has been reported that cells expressing high levels of cereblon are resistant to proteasome inhibitor, implying that patients with high levels of cereblon should be resistant to proteasome inhibitor. If the above conclusions are correct, cereblon could be considered as a biomarker to determine which standard regimens should be used to treat patients with MM. Unfortunately, the conclusions mentioned above have not been clinically confirmed. In order to confirm these conclusions, we have generated three highly specific mouse monoclonal antibodies (mAbs) against full-length human cereblon. These mAbs can be used to do western blot, immunoprecipitation and immunohistochemistry staining. In addition, their epitopes have been precisely determined and the peptides covering their epitopes completely blocked the antibody binding to cereblon in western blot analysis or in immunohistochemistry staining of MM patients' specimens. Twit Text FOAVip Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28926977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28926977 #FOAvip English Wikipedia <ref>{{Cite pmid|28926977 }}</ref> Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma #MMPMID28926977 Chang X ; Xu Q ; Hou Y ; Li C ; Xu Y ; Stewart AK Int J Mol Sci 2017[Sep]; 18 (9 ): ä PMID28926977 show ga Immunomodulatory drugs (IMiDs) are profoundly active compounds in the treatment of patients with multiple myeloma (MM). However, despite the fact that treatment with IMiDs has dramatically improved survival for patients with MM, the majority of MM patients develop IMiDs resistance over time. We have found that expression of functional cereblon is required for IMiDs' action. In addition, it has been reported that cells expressing high levels of cereblon are resistant to proteasome inhibitor, implying that patients with high levels of cereblon should be resistant to proteasome inhibitor. If the above conclusions are correct, cereblon could be considered as a biomarker to determine which standard regimens should be used to treat patients with MM. Unfortunately, the conclusions mentioned above have not been clinically confirmed. In order to confirm these conclusions, we have generated three highly specific mouse monoclonal antibodies (mAbs) against full-length human cereblon. These mAbs can be used to do western blot, immunoprecipitation and immunohistochemistry staining. In addition, their epitopes have been precisely determined and the peptides covering their epitopes completely blocked the antibody binding to cereblon in western blot analysis or in immunohistochemistry staining of MM patients' specimens. |Adaptor Proteins, Signal Transducing [MESH] |Animals [MESH] |Antibodies, Monoclonal/*immunology [MESH] |Antibody Affinity [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Immunologic Factors/*immunology [MESH] |Mice [MESH] |Multiple Myeloma/*immunology [MESH] |Peptide Hydrolases/*immunology [MESH]Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon:(epmc).pdf DeepDyve Pubget Overpricing