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10.3390/ijms18091995 http://scihub22266oqcxt.onion/10.3390/ijms18091995 C5618644!5618644!28926941     free     free     free       Int+J+Mol+Sci 2017 ; 18 (9): ä Nephropedia Template TP {{tp|p=28926941|t=2017. Why Ubiquitin Has Not Evolved |pdf=|usr=}}{{28926941}} gab.com Text Why Ubiquitin Has Not Evolved JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28926941 #FOAvip Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish, and even worms, indicating that ubiquitin is perfect. Key features of its functionality are identified here using critical point thermodynamic scaling theory. These include synchronized pivots and hinges, a stabilizing central pivot, and Fano interference between first- and second-order elements of correlated long-range (allosteric) globular surface shape transitions. Comparison with its closest relative, 76 amino acid Nedd8, shows that the latter lacks all these features. A cracked elastic network model is proposed for the common target shared by many diseased proteins. Twit Text FOAVip Why Ubiquitin Has Not Evolved ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28926941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28926941 #FOAvip English Wikipedia <ref>{{Cite pmid|28926941}}</ref> Why Ubiquitin Has Not Evolved #MMPMID28926941 Allan DC; Phillips JC Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28926941show ga Ubiquitin, discovered less than 50 years ago, tags thousands of diseased proteins for destruction. It is small (only 76 amino acids), and is found unchanged in mammals, birds, fish, and even worms, indicating that ubiquitin is perfect. Key features of its functionality are identified here using critical point thermodynamic scaling theory. These include synchronized pivots and hinges, a stabilizing central pivot, and Fano interference between first- and second-order elements of correlated long-range (allosteric) globular surface shape transitions. Comparison with its closest relative, 76 amino acid Nedd8, shows that the latter lacks all these features. A cracked elastic network model is proposed for the common target shared by many diseased proteins. äWhy Ubiquitin Has Not Evolved (epmc).pdf DeepDyve Pubget Overpricing