Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28906481
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Mol+Sci
2017 ; 18
(9
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Insights into the Diagnostic Potential of Extracellular Vesicles and Their miRNA
Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular
Complications
#MMPMID28906481
La Marca V
; Fierabracci A
Int J Mol Sci
2017[Sep]; 18
(9
): ä PMID28906481
show ga
Extracellular vesicles (EVs) represent a heterogeneous population of small
vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior
cargo. Almost all cell types release EVs, thus they are naturally present in all
body fluids. Among the several potential applications, EVs could be used as drug
delivery vehicles in disease treatment, in immune therapy because of their
immunomodulatory properties and in regenerative medicine. In addition to general
markers, EVs are characterized by the presence of specific biomarkers (proteins
and miRNAs) that allow the identification of their cell or tissue origin. For
these features, they represent a potential powerful diagnostic tool to monitor
state and progression of specific diseases. A large body of studies supports the
idea that endothelial derived (EMPs) together with platelet-derived
microparticles (PMPs) are deeply involved in the pathogenesis of diseases
characterized by micro- and macrovascular damages, including diabetes. Existing
literature suggests that the detection of circulating EMPs and PMPs and their
specific miRNA profile may represent a very useful non-invasive signature to
achieve information on the onset of peculiar disease manifestations. In this
review, we discuss the possible utility of EVs in the early diagnosis of
diabetes-associated microvascular complications, specifically related to kidney.