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10.3390/ijms18091963 http://scihub22266oqcxt.onion/10.3390/ijms18091963 C5618612!5618612!28902166     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (9): ä Nephropedia Template TP {{tp|p=28902166|t=2017. Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases |pdf=|usr=}}{{28902166}} gab.com Text Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28902166 #FOAvip Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the dynamic balancing of processes in the proteostasis network (PN). Such processes include protein synthesis, folding, and degradation in both non-stressed and stressful conditions. The role of the PN in neurodegenerative disease is well-documented, where it is known to respond to changes in protein folding states or toxic gain-of-function protein aggregation. Dual-specificity phosphatases have recently emerged as important participants in maintaining balance within the PN, acting through modulation of cellular signaling pathways that are involved in neurodegeneration. In this review, we will summarize recent findings describing the roles of dual-specificity phosphatases in neurodegeneration and offer perspectives on future therapeutic directions. Twit Text FOAVip Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28902166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902166 #FOAvip English Wikipedia <ref>{{Cite pmid|28902166}}</ref> Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases #MMPMID28902166 Bhore N; Wang BJ; Chen YW; Liao YF Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28902166show ga Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the dynamic balancing of processes in the proteostasis network (PN). Such processes include protein synthesis, folding, and degradation in both non-stressed and stressful conditions. The role of the PN in neurodegenerative disease is well-documented, where it is known to respond to changes in protein folding states or toxic gain-of-function protein aggregation. Dual-specificity phosphatases have recently emerged as important participants in maintaining balance within the PN, acting through modulation of cellular signaling pathways that are involved in neurodegeneration. In this review, we will summarize recent findings describing the roles of dual-specificity phosphatases in neurodegeneration and offer perspectives on future therapeutic directions. äCritical Roles of Dual-Specificity Phosphatases in Neuronal Proteostas(epmc).pdf DeepDyve Pubget Overpricing