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10.3390/ijms18091959

http://scihub22266oqcxt.onion/10.3390/ijms18091959
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C5618608!5618608!28895911
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suck abstract from ncbi


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pmid28895911      Int+J+Mol+Sci 2017 ; 18 (9): ä
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  • Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer #MMPMID28895911
  • Byun S; Lee E; Lee KW
  • Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28895911show ga
  • Autophagy is an essential catabolic program that forms part of the stress response and enables cells to break down their own intracellular components within lysosomes for recycling. Accumulating evidence suggests that autophagy plays vital roles in determining pathological outcomes of immune responses and tumorigenesis. Autophagy regulates innate and adaptive immunity affecting the pathologies of infectious, inflammatory, and autoimmune diseases. In cancer, autophagy appears to play distinct roles depending on the context of the malignancy by either promoting or suppressing key determinants of cancer cell survival. This review covers recent developments in the understanding of autophagy and discusses potential therapeutic interventions that may alter the outcomes of certain diseases.
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