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10.3390/ijms18091952 http://scihub22266oqcxt.onion/10.3390/ijms18091952 C5618601!5618601!28902128     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (9): ä Nephropedia Template TP {{tp|p=28902128|t=2017. Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process |pdf=|usr=}}{{28902128}} gab.com Text Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28902128 #FOAvip Evaluation of the extent and nature of induced pluripotent stem cell (iPSC) genetic instability is important for both basic research and future clinical use. As previously demonstrated regarding embryonic stem cells, such DNA aberrations might affect the differentiation capacity of the cells and increase their tumorigenicity. Here, we first focus on the contribution of multiple DNA damage response pathways during cellular reprogramming. We then discuss the origin and mechanisms responsible for the modification of genetic material in iPSCs (pre-existing variations in somatic cells, mutations induced by reprogramming factors, and mutations induced by culture expansion) and deepen the possible functional consequences of genetic variations in these cells. Lastly, we present some recent improvements of iPSC generation methods aimed at obtaining cells with fewer genetic variations. Twit Text FOAVip Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28902128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28902128 #FOAvip English Wikipedia <ref>{{Cite pmid|28902128}}</ref> Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process #MMPMID28902128 Turinetto V; Orlando L; Giachino C Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28902128show ga Evaluation of the extent and nature of induced pluripotent stem cell (iPSC) genetic instability is important for both basic research and future clinical use. As previously demonstrated regarding embryonic stem cells, such DNA aberrations might affect the differentiation capacity of the cells and increase their tumorigenicity. Here, we first focus on the contribution of multiple DNA damage response pathways during cellular reprogramming. We then discuss the origin and mechanisms responsible for the modification of genetic material in iPSCs (pre-existing variations in somatic cells, mutations induced by reprogramming factors, and mutations induced by culture expansion) and deepen the possible functional consequences of genetic variations in these cells. Lastly, we present some recent improvements of iPSC generation methods aimed at obtaining cells with fewer genetic variations. äInduced Pluripotent Stem Cells: Advances in the Quest for Genetic Stab(epmc).pdf DeepDyve Pubget Overpricing