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10.3390/ijms18091935 http://scihub22266oqcxt.onion/10.3390/ijms18091935 C5618584!5618584 !28885567     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28885567 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species |pdf=|usr=}}{{28885567 }} gab.com Text Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28885567 #FOAvip Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major challenge to clinicians as they are present in the majority of patients seen in a common outpatient epilepsy clinic and are prone to pharmacoresistance, highlighting an unmet need for new treatment strategies. Metabolic and homeostatic changes are closely linked to seizures and epilepsy, although, surprisingly, no potential treatment targets to date have been translated into clinical practice. We summarize here the current knowledge about metabolic and homeostatic changes in seizures and acquired epilepsy, maintaining a particular focus on mitochondria, calcium dynamics, reactive oxygen species and key regulators of cellular metabolism such as the Nrf2 pathway. Finally, we highlight research gaps that will need to be addressed in the future which may help to translate these findings into clinical practice. Twit Text FOAVip Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28885567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28885567 #FOAvip English Wikipedia <ref>{{Cite pmid|28885567 }}</ref> Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species #MMPMID28885567 Kovac S ; Dinkova Kostova AT ; Herrmann AM ; Melzer N ; Meuth SG ; Gorji A Int J Mol Sci 2017[Sep]; 18 (9 ): ä PMID28885567 show ga Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These epilepsies pose a major challenge to clinicians as they are present in the majority of patients seen in a common outpatient epilepsy clinic and are prone to pharmacoresistance, highlighting an unmet need for new treatment strategies. Metabolic and homeostatic changes are closely linked to seizures and epilepsy, although, surprisingly, no potential treatment targets to date have been translated into clinical practice. We summarize here the current knowledge about metabolic and homeostatic changes in seizures and acquired epilepsy, maintaining a particular focus on mitochondria, calcium dynamics, reactive oxygen species and key regulators of cellular metabolism such as the Nrf2 pathway. Finally, we highlight research gaps that will need to be addressed in the future which may help to translate these findings into clinical practice. |*Energy Metabolism [MESH] |*Homeostasis [MESH] |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Calcium Channels/metabolism [MESH] |Calcium/*metabolism [MESH] |Cell Death [MESH] |Cell Membrane/metabolism [MESH] |Endoplasmic Reticulum/metabolism [MESH] |Epilepsy/etiology/*metabolism [MESH] |Humans [MESH] |Mitochondria/*metabolism [MESH] |NF-E2-Related Factor 2/metabolism [MESH] |Oxidative Stress [MESH] |Reactive Oxygen Species/*metabolism [MESH] |Research [MESH]Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mi(epmc).pdf DeepDyve Pubget Overpricing