Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/ijms18091931 http://scihub22266oqcxt.onion/10.3390/ijms18091931 C5618580!5618580 !28885545     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28885545 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (9 ): ä Nephropedia Template TP {{tp|p=28885545 |t=2017. TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-?B Signaling |pdf=|usr=}}{{28885545 }} gab.com Text TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF- B Signaling JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28885545 #FOAvip Many of the tripartite motif (TRIM) proteins function as E3 ubiquitin ligases and are assumed to be involved in various events, including oncogenesis. In regard to tripartite motif-containing 44 (TRIM44), which is an atypical TRIM family protein lacking the RING finger domain, its pathophysiological significance in breast cancer remains unknown. We performed an immunohistochemical study of TRIM44 protein in clinical breast cancer tissues from 129 patients. The pathophysiological role of TRIM44 in breast cancer was assessed by modulating TRIM44 expression in MCF-7 and MDA-MB-231 breast cancer cells. TRIM44 strong immunoreactivity was significantly associated with nuclear grade (p = 0.033), distant disease-free survival (p = 0.031) and overall survival (p = 0.027). Multivariate analysis revealed that the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. siRNA-mediated TRIM44 knockdown significantly decreased the proliferation of MCF-7 and MDA-MB-231 cells and inhibited the migration of MDA-MB-231 cells. Microarray analysis and qRT-PCR showed that TRIM44 knockdown upregulated CDK19 and downregulated MMP1 in MDA-MB-231 cells. Notably, TRIM44 knockdown impaired nuclear factor-kappa B (NF-?B)-mediated transcriptional activity stimulated by tumor necrosis factor ? (TNF?). Moreover, TRIM44 knockdown substantially attenuated the TNF?-dependent phosphorylation of the p65 subunit of NF-?B and I?B? in both MCF-7 and MDA-MB-231 cells. TRIM44 would play a role in the progression of breast cancer by promoting cell proliferation and migration, as well as by enhancing NF-?B signaling. Twit Text FOAVip TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF- B Signaling ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28885545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28885545 #FOAvip English Wikipedia <ref>{{Cite pmid|28885545 }}</ref> TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-?B Signaling #MMPMID28885545 Kawabata H ; Azuma K ; Ikeda K ; Sugitani I ; Kinowaki K ; Fujii T ; Osaki A ; Saeki T ; Horie-Inoue K ; Inoue S Int J Mol Sci 2017[Sep]; 18 (9 ): ä PMID28885545 show ga Many of the tripartite motif (TRIM) proteins function as E3 ubiquitin ligases and are assumed to be involved in various events, including oncogenesis. In regard to tripartite motif-containing 44 (TRIM44), which is an atypical TRIM family protein lacking the RING finger domain, its pathophysiological significance in breast cancer remains unknown. We performed an immunohistochemical study of TRIM44 protein in clinical breast cancer tissues from 129 patients. The pathophysiological role of TRIM44 in breast cancer was assessed by modulating TRIM44 expression in MCF-7 and MDA-MB-231 breast cancer cells. TRIM44 strong immunoreactivity was significantly associated with nuclear grade (p = 0.033), distant disease-free survival (p = 0.031) and overall survival (p = 0.027). Multivariate analysis revealed that the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. siRNA-mediated TRIM44 knockdown significantly decreased the proliferation of MCF-7 and MDA-MB-231 cells and inhibited the migration of MDA-MB-231 cells. Microarray analysis and qRT-PCR showed that TRIM44 knockdown upregulated CDK19 and downregulated MMP1 in MDA-MB-231 cells. Notably, TRIM44 knockdown impaired nuclear factor-kappa B (NF-?B)-mediated transcriptional activity stimulated by tumor necrosis factor ? (TNF?). Moreover, TRIM44 knockdown substantially attenuated the TNF?-dependent phosphorylation of the p65 subunit of NF-?B and I?B? in both MCF-7 and MDA-MB-231 cells. TRIM44 would play a role in the progression of breast cancer by promoting cell proliferation and migration, as well as by enhancing NF-?B signaling. |*Signal Transduction [MESH] |Adult [MESH] |Aged [MESH] |Biomarkers, Tumor [MESH] |Breast Neoplasms/genetics/*metabolism/*mortality/pathology [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Intracellular Signaling Peptides and Proteins [MESH] |Middle Aged [MESH] |NF-kappa B/*metabolism [MESH] |Neoplasm Grading [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Prognosis [MESH] |Protein Binding [MESH]TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Mod(epmc).pdf DeepDyve Pubget Overpricing