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10.3390/ijms18091924 http://scihub22266oqcxt.onion/10.3390/ijms18091924 C5618573!5618573 !28880216     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28880216 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression |pdf=|usr=}}{{28880216 }} gab.com Text Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28880216 #FOAvip N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells. In addition, NAT10 inhibition significantly increased cell cycle arrest in S-phase, thereby suppressing the growth and proliferation of malignant melanoma cells in vitro and in vivo. These results demonstrate the potential role of NAT10 in melanogenesis and melanoma growth through the regulation of microphthalmia-associated transcription factor (MITF) expression and provide a promising strategy for the treatment of various skin diseases (melanoma) and pigmentation disorders (chloasma and freckles). Twit Text FOAVip Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28880216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28880216 #FOAvip English Wikipedia <ref>{{Cite pmid|28880216 }}</ref> Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression #MMPMID28880216 Oh TI ; Lee YM ; Lim BO ; Lim JH Int J Mol Sci 2017[Sep]; 18 (9 ): ä PMID28880216 show ga N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells. In addition, NAT10 inhibition significantly increased cell cycle arrest in S-phase, thereby suppressing the growth and proliferation of malignant melanoma cells in vitro and in vivo. These results demonstrate the potential role of NAT10 in melanogenesis and melanoma growth through the regulation of microphthalmia-associated transcription factor (MITF) expression and provide a promising strategy for the treatment of various skin diseases (melanoma) and pigmentation disorders (chloasma and freckles). |Animals [MESH] |Cell Cycle/drug effects/genetics [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic/drug effects/genetics [MESH] |Humans [MESH] |Hydrazones/*pharmacology [MESH] |Melanins/metabolism [MESH] |Melanocytes/drug effects/metabolism [MESH] |Melanoma/*metabolism [MESH] |Microphthalmia-Associated Transcription Factor/genetics/*metabolism [MESH] |N-Terminal Acetyltransferase A/genetics/*metabolism [MESH] |N-Terminal Acetyltransferases [MESH]Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by At(epmc).pdf DeepDyve Pubget Overpricing