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10.3390/ijms18091895 http://scihub22266oqcxt.onion/10.3390/ijms18091895 C5618544!5618544 !28869526     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28869526 &cmd=llinks): Failed to open stream: HTTP request failed! 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Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes |pdf=|usr=}}{{28869526 }} gab.com Text Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28869526 #FOAvip The HA1 subunit of the influenza virus hemagglutinin (HA) is a valuable antigen for the development of vaccines against flu due to the availability of most antigenic sites which are conformational. Therefore, a novel adjuvanted antigen delivery system, tubular immunostimulating complexes (TI-complexes) comprising monogalactosyldiacylglycerol (MGDG) from different marine macrophytes as a lipid matrix for an antigen, was applied to enhance the immunogenicity of recombinant HA1 of influenza A H1N1 and to study the relation between its immunogenicity and conformation. The content of anti-HA1 antibodies and cytokines was estimated by ELISA after the immunization of mice with HA1 alone, and HA1 was incorporated in TI-complexes based on different MGDGs isolated from green algae Ulva lactuca, brown algae Sargassum pallidum, and seagrass Zostera marina. Conformational changes of HA1 were estimated by differential scanning calorimetry and intrinsic fluorescence. It was shown that the adjuvant activity of TI-complexes depends on the microviscosity of MGDGs, which differently influence the conformation of HA1. The highest production of anti-HA1 antibodies (compared with the control) was induced by HA1 incorporated in a TI-complex based on MGDG from S. pallidum, which provided the relaxation of the spatial structure and, likely, the proper presentation of the antigen to immunocompetent cells. Twit Text FOAVip Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28869526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28869526 #FOAvip English Wikipedia <ref>{{Cite pmid|28869526 }}</ref> Modulation of Immunogenicity and Conformation of HA1 Subunit of Influenza A Virus H1/N1 Hemagglutinin in Tubular Immunostimulating Complexes #MMPMID28869526 Sanina N ; Davydova L ; Chopenko N ; Kostetsky E ; Shnyrov V Int J Mol Sci 2017[Sep]; 18 (9 ): ä PMID28869526 show ga The HA1 subunit of the influenza virus hemagglutinin (HA) is a valuable antigen for the development of vaccines against flu due to the availability of most antigenic sites which are conformational. Therefore, a novel adjuvanted antigen delivery system, tubular immunostimulating complexes (TI-complexes) comprising monogalactosyldiacylglycerol (MGDG) from different marine macrophytes as a lipid matrix for an antigen, was applied to enhance the immunogenicity of recombinant HA1 of influenza A H1N1 and to study the relation between its immunogenicity and conformation. The content of anti-HA1 antibodies and cytokines was estimated by ELISA after the immunization of mice with HA1 alone, and HA1 was incorporated in TI-complexes based on different MGDGs isolated from green algae Ulva lactuca, brown algae Sargassum pallidum, and seagrass Zostera marina. Conformational changes of HA1 were estimated by differential scanning calorimetry and intrinsic fluorescence. It was shown that the adjuvant activity of TI-complexes depends on the microviscosity of MGDGs, which differently influence the conformation of HA1. The highest production of anti-HA1 antibodies (compared with the control) was induced by HA1 incorporated in a TI-complex based on MGDG from S. pallidum, which provided the relaxation of the spatial structure and, likely, the proper presentation of the antigen to immunocompetent cells. |Adjuvants, Immunologic/chemistry [MESH] |Animals [MESH] |Antibodies, Viral/immunology [MESH] |Antigens, Viral/*chemistry/*immunology [MESH] |Calorimetry, Differential Scanning [MESH] |Cytokines/metabolism [MESH] |Galactolipids/chemistry/pharmacology [MESH] |Hemagglutinin Glycoproteins, Influenza Virus/*chemistry/*immunology [MESH] |Influenza A Virus, H1N1 Subtype/*immunology [MESH] |Influenza Vaccines/immunology [MESH] |Macrophages/drug effects/immunology/metabolism [MESH] |Male [MESH] |Mice [MESH] |Protein Conformation/drug effects [MESH]Modulation of Immunogenicity and Conformation of HA1 Subunit of Influe(epmc).pdf DeepDyve Pubget Overpricing