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10.3390/ijms18091888 http://scihub22266oqcxt.onion/10.3390/ijms18091888 C5618537!5618537!28862656     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (9): ä Nephropedia Template TP {{tp|p=28862656|t=2017. Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells |pdf=|usr=}}{{28862656}} gab.com Text Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28862656 #FOAvip Bromopropane (BP) compounds, including 1-bromopropane, 2-bromopropane, and 1,2-dibromopropane, are used in industry for various purposes, and their deleterious effects on human health are becoming known. In this study, we examined the effects of BP compounds on the stemness of colorectal cancer cells. At low, non-cytotoxic concentrations, BP compounds significantly increased spheroid formation in CSC221, DLD1, Caco2, and HT29 cells. In addition, the levels of cancer stem cell markers, such as aldehyde dehydrogenase-1, cluster of differentiation 133 (CD133), CD44, Lgr5, Musashi-1, Ephrin receptor, and Bmi-1 increased after exposure to BP compounds. BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and ?-catenin by RT-PCR. These results demonstrate for the first time that BP compounds have the potential to promote cancer stemness. Twit Text FOAVip Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28862656 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28862656 #FOAvip English Wikipedia <ref>{{Cite pmid|28862656}}</ref> Bromopropane Compounds Increase the Stemness of Colorectal Cancer Cells #MMPMID28862656 Cho YC; Nguyen TT; Park SY; Kim K; Kim HS; Jeong HG; Kim KK; Kim H Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28862656show ga Bromopropane (BP) compounds, including 1-bromopropane, 2-bromopropane, and 1,2-dibromopropane, are used in industry for various purposes, and their deleterious effects on human health are becoming known. In this study, we examined the effects of BP compounds on the stemness of colorectal cancer cells. At low, non-cytotoxic concentrations, BP compounds significantly increased spheroid formation in CSC221, DLD1, Caco2, and HT29 cells. In addition, the levels of cancer stem cell markers, such as aldehyde dehydrogenase-1, cluster of differentiation 133 (CD133), CD44, Lgr5, Musashi-1, Ephrin receptor, and Bmi-1 increased after exposure to BP compounds. BP compounds increased the transcriptional activity of the TOPflash and glioma-associated oncogene homolog zinc finger protein (Gli) promoters in reporter assays and increased the expression of Gli-1, Gli-2, Smoothened (SMO), and ?-catenin by RT-PCR. These results demonstrate for the first time that BP compounds have the potential to promote cancer stemness. äBromopropane Compounds Increase the Stemness of Colorectal Cancer Cell(epmc).pdf DeepDyve Pubget Overpricing