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10.3390/ijms18091886 http://scihub22266oqcxt.onion/10.3390/ijms18091886 C5618535!5618535!28858227     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (9): ä Nephropedia Template TP {{tp|p=28858227|t=2017. The Role of PALB2 in the DNA Damage Response and Cancer Predisposition |pdf=|usr=}}{{28858227}} gab.com Text The Role of PALB2 in the DNA Damage Response and Cancer Predisposition JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28858227 #FOAvip The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner and Localizer of Breast Cancer 2 (BRCA2)) plays an important role in maintaining genome integrity through its role in the Fanconi anemia (FA) and homologous recombination (HR) DNA repair pathways. Since its identification as a BRCA2 interacting partner, PALB2 has emerged as a pivotal tumor suppressor protein associated to hereditary cancer susceptibility to breast and pancreatic cancers. In this review, we discuss how other DDR proteins (such as the kinases Ataxia Telangiectasia Mutated (ATM) and ATM- and Rad3-Related (ATR), mediators BRCA1 (Breast Cancer 1)/BRCA2 and effectors RAD51/DNA Polymerase ? (Pol?) interact with PALB2 to orchestrate DNA repair. We also examine the involvement of PALB2 mutations in the predisposition to cancer and the role of PALB2 in stimulating error-free DNA repair through the FA/HR pathway. Twit Text FOAVip The Role of PALB2 in the DNA Damage Response and Cancer Predisposition ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28858227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28858227 #FOAvip English Wikipedia <ref>{{Cite pmid|28858227}}</ref> The Role of PALB2 in the DNA Damage Response and Cancer Predisposition #MMPMID28858227 Nepomuceno TC; De Gregoriis G; Bastos de Oliveira FM; Suarez-Kurtz G; Monteiro AN; Carvalho MA Int J Mol Sci 2017[Sep]; 18 (9): ä PMID28858227show ga The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner and Localizer of Breast Cancer 2 (BRCA2)) plays an important role in maintaining genome integrity through its role in the Fanconi anemia (FA) and homologous recombination (HR) DNA repair pathways. Since its identification as a BRCA2 interacting partner, PALB2 has emerged as a pivotal tumor suppressor protein associated to hereditary cancer susceptibility to breast and pancreatic cancers. In this review, we discuss how other DDR proteins (such as the kinases Ataxia Telangiectasia Mutated (ATM) and ATM- and Rad3-Related (ATR), mediators BRCA1 (Breast Cancer 1)/BRCA2 and effectors RAD51/DNA Polymerase ? (Pol?) interact with PALB2 to orchestrate DNA repair. We also examine the involvement of PALB2 mutations in the predisposition to cancer and the role of PALB2 in stimulating error-free DNA repair through the FA/HR pathway. äThe Role of PALB2 in the DNA Damage Response and Cancer Predisposition(epmc).pdf DeepDyve Pubget Overpricing