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10.3390/ijms18091849 http://scihub22266oqcxt.onion/10.3390/ijms18091849 C5618498!5618498 !28837080     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28837080 &cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells |pdf=|usr=}}{{28837080 }} gab.com Text Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28837080 #FOAvip Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms of tumor progression that can help to predict prognosis and to choose the best therapeutic approach for HNSCC patients. Hyaluronan (HA), an important glycosaminoglycan component of the extracellular matrix (ECM), and its major cell surface receptor, CD44, have been suggested to be important cellular mediators influencing tumor progression and treatment resistance in head and neck cancer. HNSCC contains a small subpopulation of cells that exhibit a hallmark of CD44-expressing cancer stem cell (CSC) properties with self-renewal, multipotency, and a unique potential for tumor initiation. HA has been shown to stimulate a variety of CSC functions including self-renewal, clone formation and differentiation. This review article will present current evidence for the existence of a unique small population of CD44v3(high)ALDH(high)-expressing CSCs in HNSCC. A special focus will be placed on the role of HA/CD44-induced oncogenic signaling and histone methyltransferase, DOT1L activities in regulating histone modifications (via epigenetic changes) and miRNA activation. Many of these events are essential for the CSC properties such as Nanog/Oct4/Sox2 expression, spheroid/clone formation, self-renewal, tumor cell migration/invasion, survival and chemotherapeutic drug resistance in HA-activated head and neck cancer. These newly-discovered HA/CD44-mediated oncogenic signaling pathways delineate unique tumor dynamics with implications for defining the drivers of HNSCC progression processes. Most importantly, the important knowledge obtained from HA/CD44-regulated CSC signaling and functional activation could provide new information regarding the design of novel drug targets to overcome current therapeutic drug resistance which will have significant treatment implications for head and neck cancer patients. Twit Text FOAVip Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28837080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28837080 #FOAvip English Wikipedia <ref>{{Cite pmid|28837080 }}</ref> Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Regulation and Chemoresistance in Head and Neck Cancer Stem Cells #MMPMID28837080 Bourguignon LYW ; Earle C ; Shiina M Int J Mol Sci 2017[Aug]; 18 (9 ): ä PMID28837080 show ga Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms of tumor progression that can help to predict prognosis and to choose the best therapeutic approach for HNSCC patients. Hyaluronan (HA), an important glycosaminoglycan component of the extracellular matrix (ECM), and its major cell surface receptor, CD44, have been suggested to be important cellular mediators influencing tumor progression and treatment resistance in head and neck cancer. HNSCC contains a small subpopulation of cells that exhibit a hallmark of CD44-expressing cancer stem cell (CSC) properties with self-renewal, multipotency, and a unique potential for tumor initiation. HA has been shown to stimulate a variety of CSC functions including self-renewal, clone formation and differentiation. This review article will present current evidence for the existence of a unique small population of CD44v3(high)ALDH(high)-expressing CSCs in HNSCC. A special focus will be placed on the role of HA/CD44-induced oncogenic signaling and histone methyltransferase, DOT1L activities in regulating histone modifications (via epigenetic changes) and miRNA activation. Many of these events are essential for the CSC properties such as Nanog/Oct4/Sox2 expression, spheroid/clone formation, self-renewal, tumor cell migration/invasion, survival and chemotherapeutic drug resistance in HA-activated head and neck cancer. These newly-discovered HA/CD44-mediated oncogenic signaling pathways delineate unique tumor dynamics with implications for defining the drivers of HNSCC progression processes. Most importantly, the important knowledge obtained from HA/CD44-regulated CSC signaling and functional activation could provide new information regarding the design of novel drug targets to overcome current therapeutic drug resistance which will have significant treatment implications for head and neck cancer patients. |*Epigenesis, Genetic [MESH] |*Signal Transduction [MESH] |Aldehyde Dehydrogenase 1 Family [MESH] |Animals [MESH] |Biomarkers [MESH] |Disease Progression [MESH] |Drug Resistance, Neoplasm/*genetics [MESH] |Extracellular Matrix [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Head and Neck Neoplasms/*genetics/*metabolism/pathology [MESH] |Histone Methyltransferases [MESH] |Histone-Lysine N-Methyltransferase/genetics/metabolism [MESH] |Humans [MESH] |Hyaluronan Receptors/*metabolism [MESH] |Hyaluronic Acid/chemistry/*metabolism [MESH] |Isoenzymes/metabolism [MESH] |Methyltransferases/genetics/metabolism [MESH] |MicroRNAs/genetics [MESH] |Neoplastic Stem Cells/*drug effects/*metabolism [MESH] |Protein Binding [MESH]Activation of Matrix Hyaluronan-Mediated CD44 Signaling, Epigenetic Re(epmc).pdf DeepDyve Pubget Overpricing