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10.3390/biomedicines5030056

http://scihub22266oqcxt.onion/10.3390/biomedicines5030056
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C5618314!5618314!28895912
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suck abstract from ncbi


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pmid28895912      Biomedicines 2017 ; 5 (3): ä
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  • CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases #MMPMID28895912
  • Akinrinmade OA; Chetty S; Daramola AK; Islam Mu; Thepen T; Barth S
  • Biomedicines 2017[Sep]; 5 (3): ä PMID28895912show ga
  • To date, no curative therapy is available for the treatment of most chronic inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current treatments require a lifetime supply for patients to alleviate clinical symptoms and are unable to stop the course of disease. In contrast, a new series of immunotherapeutic agents targeting the Fc ? receptor I (CD64) have emerged and demonstrated significant clinical potential to actually resolving chronic inflammation driven by M1-type dysregulated macrophages. This subpopulation plays a key role in the initiation and maintenance of a series of chronic diseases. The novel recombinant M1-specific immunotherapeutics offer the prospect of highly effective treatment strategies as they have been shown to selectively eliminate the disease-causing macrophage subpopulations. In this review, we provide a detailed summary of the data generated, together with the advantages and the clinical potential of CD64-based targeted therapies for the treatment of chronic inflammatory diseases.
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