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10.3390/biomedicines5030050 http://scihub22266oqcxt.onion/10.3390/biomedicines5030050 C5618308!5618308!28829404     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomedicines 2017 ; 5 (3): ä Nephropedia Template TP {{tp|p=28829404|t=2017. Unlocking the NF-?B Conundrum: Embracing Complexity to Achieve Specificity |pdf=|usr=}}{{28829404}} gab.com Text Unlocking the NF- B Conundrum: Embracing Complexity to Achieve Specificity JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28829404 #FOAvip Transcription factors of the nuclear factor ?B (NF-?B) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-?B activation also contributes to the pathogenesis of some of the most common current threats to global human health, including chronic inflammatory diseases, autoimmune disorders, diabetes, vascular diseases and the majority of cancers. Accordingly, the NF-?B pathway is widely considered an attractive therapeutic target in a broad range of malignant and non-malignant diseases. Yet, despite the aggressive efforts by the pharmaceutical industry to develop a specific NF-?B inhibitor, none has been clinically approved, due to the dose-limiting toxicities associated with the global suppression of NF-?B. In this review, we summarise the main strategies historically adopted to therapeutically target the NF-?B pathway with an emphasis on oncology, and some of the emerging strategies and newer agents being developed to pharmacologically inhibit this pathway. Twit Text FOAVip Unlocking the NF- B Conundrum: Embracing Complexity to Achieve Specificity ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28829404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28829404 #FOAvip English Wikipedia <ref>{{Cite pmid|28829404}}</ref> Unlocking the NF-?B Conundrum: Embracing Complexity to Achieve Specificity #MMPMID28829404 Begalli F; Bennett J; Capece D; Verzella D; D?Andrea D; Tornatore L; Franzoso G Biomedicines 2017[Sep]; 5 (3): ä PMID28829404show ga Transcription factors of the nuclear factor ?B (NF-?B) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-?B activation also contributes to the pathogenesis of some of the most common current threats to global human health, including chronic inflammatory diseases, autoimmune disorders, diabetes, vascular diseases and the majority of cancers. Accordingly, the NF-?B pathway is widely considered an attractive therapeutic target in a broad range of malignant and non-malignant diseases. Yet, despite the aggressive efforts by the pharmaceutical industry to develop a specific NF-?B inhibitor, none has been clinically approved, due to the dose-limiting toxicities associated with the global suppression of NF-?B. In this review, we summarise the main strategies historically adopted to therapeutically target the NF-?B pathway with an emphasis on oncology, and some of the emerging strategies and newer agents being developed to pharmacologically inhibit this pathway. äUnlocking the NF-?B Conundrum: Embracing Complexity to Achieve Specifi(epmc).pdf DeepDyve Pubget Overpricing