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10.3390/biom7030051 http://scihub22266oqcxt.onion/10.3390/biom7030051 C5618232!5618232!28686218     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2017 ; 7 (3): ä Nephropedia Template TP {{tp|p=28686218|t=2017. Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells |pdf=|usr=}}{{28686218}} gab.com Text Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=28686218 #FOAvip The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth in eukaryotic cells. The active mTORC1 promotes cellular anabolic processes including protein, pyrimidine, and lipid biosynthesis, and inhibits catabolic processes such as autophagy. Consistent with its growth-promoting functions, hyper-activation of mTORC1 signaling is one of the important pathomechanisms underlying major human health problems including diabetes, neurodegenerative disorders, and cancer. The mTORC1 receives multiple upstream signals such as an abundance of amino acids and growth factors, thus it regulates a wide range of downstream events relevant to cell growth and proliferation control. The regulation of mTORC1 by amino acids is a fast-evolving field with its detailed mechanisms currently being revealed as the precise picture emerges. In this review, we summarize recent progress with respect to biochemical and biological findings in the regulation of mTORC1 signaling on the lysosomal membrane by amino acids. Twit Text FOAVip Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=28686218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28686218 #FOAvip English Wikipedia <ref>{{Cite pmid|28686218}}</ref> Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells #MMPMID28686218 Yao Y; Jones E; Inoki K Biomolecules 2017[Sep]; 7 (3): ä PMID28686218show ga The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth in eukaryotic cells. The active mTORC1 promotes cellular anabolic processes including protein, pyrimidine, and lipid biosynthesis, and inhibits catabolic processes such as autophagy. Consistent with its growth-promoting functions, hyper-activation of mTORC1 signaling is one of the important pathomechanisms underlying major human health problems including diabetes, neurodegenerative disorders, and cancer. The mTORC1 receives multiple upstream signals such as an abundance of amino acids and growth factors, thus it regulates a wide range of downstream events relevant to cell growth and proliferation control. The regulation of mTORC1 by amino acids is a fast-evolving field with its detailed mechanisms currently being revealed as the precise picture emerges. In this review, we summarize recent progress with respect to biochemical and biological findings in the regulation of mTORC1 signaling on the lysosomal membrane by amino acids. äLysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells (epmc).pdf DeepDyve Pubget Overpricing