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10.1021/jacs.7b06503 http://scihub22266oqcxt.onion/10.1021/jacs.7b06503 C5618142!5618142!28762738     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2017 ; 139 (34): 11998-2002 Nephropedia Template TP {{tp|p=28762738|t=2017. Enzyme-Mediated Directional Transport of a Small-Molecule Walker With Chemically Identical Feet |pdf=|usr=}}{{28762738}} gab.com Text Enzyme-Mediated Directional Transport of a Small-Molecule Walker With Chemically Identical Feet JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=28762738 #FOAvip We describe a small-molecule ?walker? that uses enzyme catalysis to discriminate between the relative positions of its ?feet? on a track and thereby move with net directionality. The bipedal walker has identical carboxylic acid feet, and ?steps? along an isotactic hydroxyl-group-derivatized polyether track by the formation/breakage of ester linkages. Lipase AS catalyzes the selective hydrolysis of the rear foot of macrocyclized walkers (an information ratchet mechanism), the rear foot producing an (R)-stereocenter at its point of attachment to the track. If the hydrolyzed foot reattaches to the track in front of the bound foot it forms an (S)-stereocenter, which is resistant to enzymatic hydrolysis. Only macrocyclic walker-track conjugates are efficiently hydrolyzed by the enzyme, leading to high processivity of the walker movement along the track. Conventional chemical reagents promote formation of the ester bonds between the walker and the track. Iterative macrocyclization and hydrolysis reactions lead to 68% of walkers taking two steps directionally along a three-foothold track. Twit Text FOAVip Enzyme-Mediated Directional Transport of a Small-Molecule Walker With Chemically Identical Feet ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=28762738 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28762738 #FOAvip English Wikipedia <ref>{{Cite pmid|28762738}}</ref> Enzyme-Mediated Directional Transport of a Small-Molecule Walker With Chemically Identical Feet #MMPMID28762738 Martin C; Lee ATL; Adams RW; Leigh DA J Am Chem Soc 2017[Aug]; 139 (34): 11998-2002 PMID28762738show ga We describe a small-molecule ?walker? that uses enzyme catalysis to discriminate between the relative positions of its ?feet? on a track and thereby move with net directionality. The bipedal walker has identical carboxylic acid feet, and ?steps? along an isotactic hydroxyl-group-derivatized polyether track by the formation/breakage of ester linkages. Lipase AS catalyzes the selective hydrolysis of the rear foot of macrocyclized walkers (an information ratchet mechanism), the rear foot producing an (R)-stereocenter at its point of attachment to the track. If the hydrolyzed foot reattaches to the track in front of the bound foot it forms an (S)-stereocenter, which is resistant to enzymatic hydrolysis. Only macrocyclic walker-track conjugates are efficiently hydrolyzed by the enzyme, leading to high processivity of the walker movement along the track. Conventional chemical reagents promote formation of the ester bonds between the walker and the track. Iterative macrocyclization and hydrolysis reactions lead to 68% of walkers taking two steps directionally along a three-foothold track. äEnzyme-Mediated Directional Transport of a Small-Molecule Walker With (epmc).pdf DeepDyve Pubget Overpricing