Clinical Approach to the Patient with AKI and Sepsis #MMPMID25795496
Godin M; Murray P; Mehta RL
Semin Nephrol 2015[Jan]; 35 (1): 12-22 PMID25795496show ga
Sepsis and AKI are frequently combined in critical care patients. They are both independently associated with increased mortality and morbidity. AKI may precede, coincide with, or follow sepsis diagnosis. Risk factors for sepsis followed by AKI differ from those associated with AKI preceding or coinciding with sepsis and the pathophysiologic mechanisms may be different. In this article, we review the available clinical, laboratory and imaging tools available for the recognition of septic AKI. Early identification of high-risk patients and targeted preventive and therapeutic measures are key in reducing mortality and morbidity of the complex syndrome of septic AKI.