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10.7554/eLife.28899 http://scihub22266oqcxt.onion/10.7554/eLife.28899 C5617631!5617631 !28901286     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28901286 &cmd=llinks): Failed to open stream: HTTP request failed! 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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye |pdf=|usr=}}{{28901286 }} gab.com Text Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28901286 #FOAvip Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Müller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss. Twit Text FOAVip Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28901286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28901286 #FOAvip English Wikipedia <ref>{{Cite pmid|28901286 }}</ref> Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye #MMPMID28901286 Kanow MA ; Giarmarco MM ; Jankowski CS ; Tsantilas K ; Engel AL ; Du J ; Linton JD ; Farnsworth CC ; Sloat SR ; Rountree A ; Sweet IR ; Lindsay KJ ; Parker ED ; Brockerhoff SE ; Sadilek M ; Chao JR ; Hurley JB Elife 2017[Sep]; 6 (ä): ä PMID28901286 show ga Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Müller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss. |*Adaptation, Ocular [MESH] |*Energy Metabolism [MESH] |Animals [MESH] |Ependymoglial Cells/metabolism/*physiology [MESH] |Glucose/metabolism [MESH] |Humans [MESH] |Lactates/metabolism [MESH] |Mice [MESH] |Photoreceptor Cells/metabolism/*physiology [MESH] |Retinal Pigment Epithelium/metabolism/*physiology [MESH]Biochemical adaptations of the retina and retinal pigment epithelium s(epmc).pdf DeepDyve Pubget Overpricing