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10.1073/pnas.1712837114 http://scihub22266oqcxt.onion/10.1073/pnas.1712837114 C5617315!5617315!28878025     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (38): 10178-83 Nephropedia Template TP {{tp|p=28878025|t=2017. Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis |pdf=|usr=}}{{28878025}} gab.com Text Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28878025 #FOAvip The imbalance in the intestinal microbiota repertoire, called dysbiosis, underlies the development of inflammatory diseases in the intestine and distant organ systems. Whether and how distant organs regulate the commensal gut bacteria and intestinal homeostasis via microbe-targeted molecules has remained poorly explored. In this study, we show that the gallbladder regulates intestinal immune homeostasis through the production of surfactant protein D (SP-D) that is delivered to the intestine via bile. The importance of the gallbladder-derived SP-D was underscored by an intestinal dysbiosis in SP-D?deficient mice and susceptibility of these mice to dextran sodium sulfate sodium-induced colitis. Our study thus revealed a unique interorgan regulation of intestinal homeostasis by SP-D with potential clinical implications such as cholecystectomy. Twit Text FOAVip Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28878025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28878025 #FOAvip English Wikipedia <ref>{{Cite pmid|28878025}}</ref> Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis #MMPMID28878025 Sarashina-Kida H; Negishi H; Nishio J; Suda W; Nakajima Y; Yasui-Kato M; Iwaisako K; Kang S; Endo N; Yanai H; Asagiri M; Kida H; Hattori M; Kumanogoh A; Taniguchi T Proc Natl Acad Sci U S A 2017[Sep]; 114 (38): 10178-83 PMID28878025show ga The imbalance in the intestinal microbiota repertoire, called dysbiosis, underlies the development of inflammatory diseases in the intestine and distant organ systems. Whether and how distant organs regulate the commensal gut bacteria and intestinal homeostasis via microbe-targeted molecules has remained poorly explored. In this study, we show that the gallbladder regulates intestinal immune homeostasis through the production of surfactant protein D (SP-D) that is delivered to the intestine via bile. The importance of the gallbladder-derived SP-D was underscored by an intestinal dysbiosis in SP-D?deficient mice and susceptibility of these mice to dextran sodium sulfate sodium-induced colitis. Our study thus revealed a unique interorgan regulation of intestinal homeostasis by SP-D with potential clinical implications such as cholecystectomy. äGallbladder-derived surfactant protein D regulates gut commensal bacte(epmc).pdf DeepDyve Pubget Overpricing