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2017 ; 114
(38
): 10178-10183
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gab.com Text
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Gallbladder-derived surfactant protein D regulates gut commensal bacteria for
maintaining intestinal homeostasis
#MMPMID28878025
Sarashina-Kida H
; Negishi H
; Nishio J
; Suda W
; Nakajima Y
; Yasui-Kato M
; Iwaisako K
; Kang S
; Endo N
; Yanai H
; Asagiri M
; Kida H
; Hattori M
; Kumanogoh A
; Taniguchi T
Proc Natl Acad Sci U S A
2017[Sep]; 114
(38
): 10178-10183
PMID28878025
show ga
The commensal microbiota within the gastrointestinal tract is essential in
maintaining homeostasis. Indeed, dysregulation in the repertoire of microbiota
can result in the development of intestinal immune-inflammatory diseases.
Further, this immune regulation by gut microbiota is important systemically,
impacting health and disease of organ systems beyond the local environment of the
gut. What has not been explored is how distant organs might in turn shape the
microbiota via microbe-targeted molecules. Here, we provide evidence that
surfactant protein D (SP-D) synthesized in the gallbladder and delivered into
intestinal lumen binds selectively to species of gut commensal bacteria.
SP-D-deficient mice manifest intestinal dysbiosis and show a susceptibility to
dextran sulfate sodium-induced colitis. Further, fecal transfer from
SP-D-deficient mice to wild-type, germ-free mice conveyed colitis susceptibility.
Interestingly, colitis caused a notable increase in Sftpd gene expression in the
gallbladder, but not in the lung, via the activity of glucocorticoids produced in
the liver. These findings describe a unique mechanism of interorgan regulation of
intestinal immune homeostasis by SP-D with potential clinical implications such
as cholecystectomy.
|*Gastrointestinal Microbiome
[MESH]
|Animals
[MESH]
|Colitis/*metabolism/microbiology
[MESH]
|Forkhead Transcription Factors/metabolism
[MESH]
|Gallbladder/*metabolism
[MESH]
|Glucocorticoids/biosynthesis
[MESH]
|Homeostasis
[MESH]
|Intestinal Mucosa/immunology
[MESH]
|Liver/metabolism
[MESH]
|Mice, Inbred C57BL
[MESH]
|Pulmonary Surfactant-Associated Protein D/*metabolism
[MESH]
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