Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1708573114 http://scihub22266oqcxt.onion/10.1073/pnas.1708573114 C5617294!5617294!28874554     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (38): E7875-81 Nephropedia Template TP {{tp|p=28874554|t=2017. Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides |pdf=|usr=}}{{28874554}} gab.com Text Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28874554 #FOAvip We have developed a model of T cell binding that accurately represents the influence of self-peptides on thymic negative selection. From this, we generated estimates for relevant antigen recognition rates. We found that negative selection only slightly interferes with a T cell?s ability to detect antigens that differ from self-peptide by a single amino acid and that these peptides may effectively be regarded as foreign. Moreover, negative selection thresholds chosen to reflect experimentally observed thymic survival rates result in optimal production of T cells that are capable of surviving selection and recognizing foreign antigen. Lastly, our model predicts empirically reasonable donor tissue recognition rates in the context of an HLA-matched transplant. Twit Text FOAVip Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28874554 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28874554 #FOAvip English Wikipedia <ref>{{Cite pmid|28874554}}</ref> Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides #MMPMID28874554 George JT; Kessler DA; Levine H Proc Natl Acad Sci U S A 2017[Sep]; 114 (38): E7875-81 PMID28874554show ga We have developed a model of T cell binding that accurately represents the influence of self-peptides on thymic negative selection. From this, we generated estimates for relevant antigen recognition rates. We found that negative selection only slightly interferes with a T cell?s ability to detect antigens that differ from self-peptide by a single amino acid and that these peptides may effectively be regarded as foreign. Moreover, negative selection thresholds chosen to reflect experimentally observed thymic survival rates result in optimal production of T cells that are capable of surviving selection and recognizing foreign antigen. Lastly, our model predicts empirically reasonable donor tissue recognition rates in the context of an HLA-matched transplant. äEffects of thymic selection on T cell recognition of foreign and tumor(epmc).pdf DeepDyve Pubget Overpricing