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10.1073/pnas.1703100114 http://scihub22266oqcxt.onion/10.1073/pnas.1703100114 C5617261!5617261 !28874534     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28874534 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (38 ): 10190-10195 Nephropedia Template TP {{tp|p=28874534 |t=2017. Treg-specific IL-27R? deletion uncovers a key role for IL-27 in Treg function to control autoimmunity |pdf=|usr=}}{{28874534 }} gab.com Text Treg-specific IL-27R deletion uncovers a key role for IL-27 in Treg function to control autoimmunity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28874534 #FOAvip Dysregulated Foxp3(+) Treg functions result in uncontrolled immune activation and autoimmunity. Therefore, identifying cellular factors modulating Treg functions is an area of great importance. Here, using Treg-specific Il27ra(-/-) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs to control autoimmune inflammation in the central nervous system (CNS). Following experimental autoimmune encephalomyelitis (EAE) induction, Treg-specific Il27ra(-/-) mice develop more severe EAE. Consistent with the severe disease, the numbers of IFN?- and IL-17-producing CD4 T cells infiltrating the CNS tissues are greater in these mice. Treg accumulation in the inflamed CNS tissues is not affected by the lack of IL-27 signaling in Tregs, suggesting a functional defect of Il27ra(-/-) Tregs. IL-10 production by conventional CD4 T cells and their CNS accumulation are rather elevated in Treg-specific Il27ra(-/-) mice. Analysis with Treg fate-mapping reporter mice further demonstrates that IL-27 signaling in Tregs may control stability of Foxp3 expression. Finally, systemic administration of recombinant IL-27 in Treg-specific Il27ra(-/-) mice fails to ameliorate the disease even in the presence of IL-27-responsive conventional CD4 T cells. These findings uncover a previously unknown role of IL-27 in regulating Treg function to control autoimmune inflammation. Twit Text FOAVip Treg-specific IL-27R deletion uncovers a key role for IL-27 in Treg function to control autoimmunity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28874534 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28874534 #FOAvip English Wikipedia <ref>{{Cite pmid|28874534 }}</ref> Treg-specific IL-27R? deletion uncovers a key role for IL-27 in Treg function to control autoimmunity #MMPMID28874534 Do J ; Kim D ; Kim S ; Valentin-Torres A ; Dvorina N ; Jang E ; Nagarajavel V ; DeSilva TM ; Li X ; Ting AH ; Vignali DAA ; Stohlman SA ; Baldwin WM 3rd ; Min B Proc Natl Acad Sci U S A 2017[Sep]; 114 (38 ): 10190-10195 PMID28874534 show ga Dysregulated Foxp3(+) Treg functions result in uncontrolled immune activation and autoimmunity. Therefore, identifying cellular factors modulating Treg functions is an area of great importance. Here, using Treg-specific Il27ra(-/-) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential for Tregs to control autoimmune inflammation in the central nervous system (CNS). Following experimental autoimmune encephalomyelitis (EAE) induction, Treg-specific Il27ra(-/-) mice develop more severe EAE. Consistent with the severe disease, the numbers of IFN?- and IL-17-producing CD4 T cells infiltrating the CNS tissues are greater in these mice. Treg accumulation in the inflamed CNS tissues is not affected by the lack of IL-27 signaling in Tregs, suggesting a functional defect of Il27ra(-/-) Tregs. IL-10 production by conventional CD4 T cells and their CNS accumulation are rather elevated in Treg-specific Il27ra(-/-) mice. Analysis with Treg fate-mapping reporter mice further demonstrates that IL-27 signaling in Tregs may control stability of Foxp3 expression. Finally, systemic administration of recombinant IL-27 in Treg-specific Il27ra(-/-) mice fails to ameliorate the disease even in the presence of IL-27-responsive conventional CD4 T cells. These findings uncover a previously unknown role of IL-27 in regulating Treg function to control autoimmune inflammation. |Animals [MESH] |Autoimmune Diseases/drug therapy/*immunology [MESH] |Central Nervous System/immunology [MESH] |Drug Evaluation, Preclinical [MESH] |Encephalomyelitis/drug therapy/*immunology [MESH] |Forkhead Transcription Factors/metabolism [MESH] |Interleukins/metabolism/therapeutic use [MESH] |Mice, Transgenic [MESH] |Receptors, Cytokine/genetics/*metabolism [MESH] |Receptors, Interleukin [MESH]Treg-specific IL-27R? deletion uncovers a key role for IL-27 in Treg f(epmc).pdf DeepDyve Pubget Overpricing