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10.1073/pnas.1700858114 http://scihub22266oqcxt.onion/10.1073/pnas.1700858114 C5617250!5617250!28794279     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (38): 10226-31 Nephropedia Template TP {{tp|p=28794279|t=2017. Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive V?-specific T cells |pdf=|usr=}}{{28794279}} gab.com Text Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive V -specific T cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28794279 #FOAvip Superantigen toxins were defined over 25 years ago for their ability to activate T cells in a T-cell receptor ?-chain variable domain-dependent manner. This ?V?-specific? T-cell activation is the hallmark feature of the superantigen, and although these toxins can mediate dangerous human disease such as toxic shock syndrome, mechanisms that explain why bacteria produce superantigens have remained enigmatic. Herein, we provide evidence that Streptococcus pyogenes utilizes superantigens to target functional, V?-specific T cells to promote a state of colonization providing a mechanism that helps explain why bacteria produce toxins that specifically activate T cells of the adaptive immune system. This work also implicates the superantigen exotoxins as potential vaccine candidates against this globally important, human-specific pathogen. Twit Text FOAVip Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive V -specific T cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28794279 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28794279 #FOAvip English Wikipedia <ref>{{Cite pmid|28794279}}</ref> Nasopharyngeal infection by Streptococcus pyogenes requires superantigen-responsive V?-specific T cells #MMPMID28794279 Zeppa JJ; Kasper KJ; Mohorovic I; Mazzuca DM; Haeryfar SMM; McCormick JK Proc Natl Acad Sci U S A 2017[Sep]; 114 (38): 10226-31 PMID28794279show ga Superantigen toxins were defined over 25 years ago for their ability to activate T cells in a T-cell receptor ?-chain variable domain-dependent manner. This ?V?-specific? T-cell activation is the hallmark feature of the superantigen, and although these toxins can mediate dangerous human disease such as toxic shock syndrome, mechanisms that explain why bacteria produce superantigens have remained enigmatic. Herein, we provide evidence that Streptococcus pyogenes utilizes superantigens to target functional, V?-specific T cells to promote a state of colonization providing a mechanism that helps explain why bacteria produce toxins that specifically activate T cells of the adaptive immune system. This work also implicates the superantigen exotoxins as potential vaccine candidates against this globally important, human-specific pathogen. äNasopharyngeal infection by Streptococcus pyogenes requires superantig(epmc).pdf DeepDyve Pubget Overpricing