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2016 ; 3
(ä): 584-590
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Virgin olive oil ameliorates deltamethrin-induced nephrotoxicity in mice: A
biochemical and immunohistochemical assessment
#MMPMID28959581
Khalatbary AR
; Ahmadvand H
; Ghabaee DNZ
; Malekshah AK
; Navazesh A
Toxicol Rep
2016[]; 3
(ä): 584-590
PMID28959581
show ga
OBJECTIVE: A major class of synthetic pyrethroid insecticide, deltamethrin (DM),
can elicit pathophysiological effects through oxidative stress in non-targeted
organisms such as mammals. There is accumulating evidence that virgin olive oil
(VOO), a rich source of polyphenolic components, have anti-oxidant,
anti-inflammatory, and anti-apoptotic properties. This study aimed to determine
the protective and ameliorative effects of VOO against DM-induced nephrotoxicity.
METHODS & MATERIALS: Mice were randomly divided into four equal groups: DM group,
DM plus VOO group, VOO group, and vehicle group. Five weeks after gavaging,
kidney samples were taken for biochemical assessment of malondialdehyde (MDA),
glutathione (GSH) and catalase (CAT), and for immunohistochemical assessment of
caspase-3, cyclooxygenase-2 (cox-2) and poly (ADP-ribose) polymerase (PARP).
RESULTS: The MDA level in kidney was increased in the DM group, which was
significantly decreased after VOO administration in the DM plus VOO group. The
GSH level and CAT activiy in kidney were decreased in the DM group, which were
significantly increased after VOO administration in the DM plus VOO group.
Greater expression of caspase-3, cox-2, and PARP could be detected in the DM
group, which was significantly attenuated in the DM plus VOO group. Also, the
histopathological changes which were detected in the DM group attenuated after
VOO consumption. CONCLUSION: Virgin olive oil exerted protective effects against
deltamethrin-induced nephrotoxicity, which might be associated with its
anti-apoptotic, anti-inflammatory, and anti-oxidative properties.
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