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2016 ; 3
(ä): 563-571
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Antigenotoxic effects of a polyherbal drug septilin against the genotoxicity of
cyclophosphamide in mice
#MMPMID28959580
Shruthi S
; Vijayalaxmi KK
Toxicol Rep
2016[]; 3
(ä): 563-571
PMID28959580
show ga
Septilin (Spt) is a polyherbal drug formulation from Himalaya Drug Company,
consisting of extracts from different medicinal plants and minerals. In the
traditional system of medicine, septilin is being used as immunomodulatory,
antioxidant and anti-inflammatory agent. In the present study, the protective
effects of septilin against the genotoxicity of cyclophosphamide (CP) a widely
used alkylating anticancer drug was evaluated by using in vivo micronucleus (MN)
and sperm shape abnormality assays in Swiss albino mice. CP administered
intraperitoneally at a dose of 50 mg/kg b.w. was used as positive mutagen.
Different doses of septilin viz., 125, 250 and 500 mg/kg b.w. was orally
administered for 5 consecutive days. CP was administered intraperitoneally on 5th
day. MN and sperm preparations were made after 24 h and 35 days respectively. CP
induced significant MN in both bone marrow and peripheral blood cells and also a
high frequency of abnormal sperms. In septilin supplemented animals, no
significant induction of MN and abnormal sperms was recorded. In septilin
supplemented groups, a dose dependent significant decrease in CP induced
clastogenicity was observed. Thus the current in vivo study revealed the
antigenotoxic effects of septilin against CP induced damage, in both somatic and
germ cells of Swiss albino mice.