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10.1016/j.toxrep.2016.04.003 http://scihub22266oqcxt.onion/10.1016/j.toxrep.2016.04.003 C5615927!5615927!28959567     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Rep 2016 ; 3 (ä): 450-7 Nephropedia Template TP {{tp|p=28959567|t=2016. Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity |pdf=|usr=}}{{28959567}} gab.com Text Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity JO: Toxicol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28959567 #FOAvip Background: Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases. Purpose: The present study was designed to examine whether C1P could protect cochlear hair cells against cisplatin ototoxicity. Materials and methods: Explants of cochlear basal turns collected from C57BL/6J mice at postnatal days 3?5 were used in all experiments. Cochlear explants were exposed to 5 or 10 ?M cisplatin for 48 h to assess the effects of C1P, NVP-231 (a ceramide kinase inhibitor), or ceramide. Western blotting of pAkt/Akt and pMAPK/MAPK was examined to check whether this pathway was modulated by C1P. Results: C1P activated the Akt and MAPK pathway and significantly reduced cochlear cell death induced by cisplatin. Coadministration of cisplatin and ceramide significantly increased cochlear hair cell death. In addition, when treating cochlear hair cells with NVP-231 in the presence of cisplatin or ceramide, a remarkable increase in apoptosis of hair cells was observed. Conclusion: The present findings confirmed the protective effects of C1P in the cisplatin ototoxicity. The balance between ceramide and C1P may play a critical role in the determination of hair cell fate in cisplatin ototoxicity. Twit Text FOAVip Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity ????Toxicol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28959567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28959567 #FOAvip English Wikipedia <ref>{{Cite pmid|28959567}}</ref> Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity #MMPMID28959567 Le Q; Tabuchi K; Hara A Toxicol Rep 2016[]; 3 (ä): 450-7 PMID28959567show ga Background: Ceramide-1-phosphate (C1P) is a phosphorylated form of ceramide. While ceramide is known to be an inducer of apoptosis of cochlear hair cells in cisplatin ototoxicity, little is known about the function of C1P in cochlear diseases. Purpose: The present study was designed to examine whether C1P could protect cochlear hair cells against cisplatin ototoxicity. Materials and methods: Explants of cochlear basal turns collected from C57BL/6J mice at postnatal days 3?5 were used in all experiments. Cochlear explants were exposed to 5 or 10 ?M cisplatin for 48 h to assess the effects of C1P, NVP-231 (a ceramide kinase inhibitor), or ceramide. Western blotting of pAkt/Akt and pMAPK/MAPK was examined to check whether this pathway was modulated by C1P. Results: C1P activated the Akt and MAPK pathway and significantly reduced cochlear cell death induced by cisplatin. Coadministration of cisplatin and ceramide significantly increased cochlear hair cell death. In addition, when treating cochlear hair cells with NVP-231 in the presence of cisplatin or ceramide, a remarkable increase in apoptosis of hair cells was observed. Conclusion: The present findings confirmed the protective effects of C1P in the cisplatin ototoxicity. The balance between ceramide and C1P may play a critical role in the determination of hair cell fate in cisplatin ototoxicity. äCeramide-1-phosphate protection of cochlear hair cells against cisplat(epmc).pdf DeepDyve Pubget Overpricing