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10.1016/j.toxrep.2016.01.006 http://scihub22266oqcxt.onion/10.1016/j.toxrep.2016.01.006 C5615789!5615789!28959534     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Rep 2016 ; 3 (ä): 153-9 Nephropedia Template TP {{tp|p=28959534|t=2016. Nrf2 activators as potential modulators of injury in human kidney cells |pdf=|usr=}}{{28959534}} gab.com Text Nrf2 activators as potential modulators of injury in human kidney cells JO: Toxicol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28959534 #FOAvip Cisplatin is a chemotherapeutic agent used in the treatment of solid tumors, with clinical use often complicated by kidney toxicity. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) is a transcription factor involved in kidney protectant effects. The purpose of this study was to determine whether the Nrf2 activators oltipraz, sulforaphane, and oleanolic acid could protect human kidney cells against cisplatin-induced injury and to compare the protective effects between three Nrf2 activators. Human proximal tubule cells (hPTC) and human embryonic kidney 293 cells (HEK293) were exposed to cisplatin doses in the absence and presence of Nrf2 activators. Pre- and delayed-cisplatin and Nrf2 activator exposures were also assessed. Cell viability was enhanced with Nrf2 activator exposures, with differences detected between pre- and delayed-treatments. Both sulforaphane and oltipraz increased the expression of anti-oxidant genes GCLC and NQO1. These findings suggest potential human kidney protective benefits of Nrf2 activators with planned exposures to cisplatin. Twit Text FOAVip Nrf2 activators as potential modulators of injury in human kidney cells ????Toxicol Rep http://www.kidney.de/pget.php?&tw=1&pmid=28959534 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28959534 #FOAvip English Wikipedia <ref>{{Cite pmid|28959534}}</ref> Nrf2 activators as potential modulators of injury in human kidney cells #MMPMID28959534 Atilano-Roque A; Wen X; Aleksunes LM; Joy MS Toxicol Rep 2016[]; 3 (ä): 153-9 PMID28959534show ga Cisplatin is a chemotherapeutic agent used in the treatment of solid tumors, with clinical use often complicated by kidney toxicity. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) is a transcription factor involved in kidney protectant effects. The purpose of this study was to determine whether the Nrf2 activators oltipraz, sulforaphane, and oleanolic acid could protect human kidney cells against cisplatin-induced injury and to compare the protective effects between three Nrf2 activators. Human proximal tubule cells (hPTC) and human embryonic kidney 293 cells (HEK293) were exposed to cisplatin doses in the absence and presence of Nrf2 activators. Pre- and delayed-cisplatin and Nrf2 activator exposures were also assessed. Cell viability was enhanced with Nrf2 activator exposures, with differences detected between pre- and delayed-treatments. Both sulforaphane and oltipraz increased the expression of anti-oxidant genes GCLC and NQO1. These findings suggest potential human kidney protective benefits of Nrf2 activators with planned exposures to cisplatin. äNrf2 activators as potential modulators of injury in human kidney cell(epmc).pdf DeepDyve Pubget Overpricing